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Journal of Endocrinology (2008) 198, 439-450       DOI: 10.1677/JOE-08-0161
© 2008 Society for Endocrinology
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REVIEW

Hedgehog signalling in endocrine development and disease

Peter J King, Leonardo Guasti and Ed Laufer1

Barts and the London School of Medicine, Centre for Endocrinology, London EC1M 6BQ, UK1 Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York 10032, USA

(Correspondence should be addressed to P J King; Email: p.j.king{at}qmul.ac.uk)

The hedgehog (Hh) pathway is an evolutionarily conserved signalling pathway that is required for many essential tissue and cellular properties such as patterning fields of cells or regulating cell differentiation and proliferation. Disruption of the pathway results in serious pathologies. In this review, we provide an update on recent findings in the field of vertebrate Hh signalling and also describe contributions of Hh signalling to the development, maintenance and pathology of endocrine tissues.




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