Searching journal content for articles similar to Wen and Yang 58 (2): R73.

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  1. Review:
    • Rebecca H Ritchie,
    • Eser J Zerenturk,
    • Darnel Prakoso,
    • and Anna C Calkin
    Lipid metabolism and its implications for type 1 diabetes-associated cardiomyopathy J Mol Endocrinol 58 (4) R225-R240, doi: 10.1530/JME-16-0249 first published on 3 April 2017
    ... et al. 1974). Although the concept of diabetic cardiomyopathy is often considered in individuals specifically affected by type 2 diabetes (T2D), a metabolically induced cardiomyopathy, independent of hypertension, nephropathy or ischaemic heart disease is also evident in individuals with type 1 diabetes (T1D...
  2. Review:
    • Zodwa Dlamini,
    • Fortunate Mokoena,
    • and Rodney Hull
    Abnormalities in alternative splicing in diabetes: therapeutic targets J Mol Endocrinol 59 (2) R93-R107, doi: 10.1530/JME-17-0049
    ...of frequency within the regions coding for the MHC region (Noble & Valdes 2011). It is known that the genetic risk of type 1 diabetes is highly associated with this MHC region (40% of the genetic risk associated with type 1 diabetes) (Vandiedonck et al. 2011). Type 2 diabetes is characterised by insulin...
  3. Review:
    • Haihua Yang and
    • Linghai Yang
    Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy J Mol Endocrinol 57 (2) R93-R108, doi: 10.1530/JME-15-0316 first published on 18 May 2016
    ...therapeutic treatment of type 2 diabetes mellitus (T2D). cAMP/PKA pathway cAMP was initially discovered as an intracellular mediator of the glycogenolytic effect of glucagon and epinephrine in the liver (Berthet et al. 1957). It was later revealed in skeletal muscle that the glycogenolytic effect of c...
  4. Research:
    • Guojun Shi,
    • Chen Sun,
    • Weiqiong Gu,
    • Minglan Yang,
    • Xiaofang Zhang,
    • Nan Zhai,
    • Yan Lu,
    • Zhijian Zhang,
    • Peishun Shou,
    • Zhiguo Zhang,
    • and Guang Ning
    Free fatty acid receptor 2, a candidate target for type 1 diabetes, induces cell apoptosis through ERK signaling J Mol Endocrinol 53 (3) 367-380, doi: 10.1530/JME-14-0065 first published on 8 October 2014
    ...et al. 2010,Introduction Type 1 diabetes (T1D) is a multi-factorial, organ-specific autoimmune disease, characterized by selective and into the pancreatic islets of along with elevated levelsThe human FFAR2 promoter regions were cloned, and luciferase reporter assays revealed that NFkB activation...
  5. Review:
    • Daniel Raleigh,
    • Xiaoxue Zhang,
    • Benoît Hastoy,
    • and Anne Clark
    The β-cell assassin: IAPP cytotoxicity J Mol Endocrinol 59 (3) R121-R140, doi: 10.1530/JME-17-0105 first published on 15 August 2017
    ...-recognising oligomeric IAPP has identified cytoplasmic material in β-cells of hIAPP transgenic mice and patients with type 2 diabetes; this pathology of cytoplasmic ‘toxic oligomers’ has been proposed to form an unifying hypothesis for loss of insulin-secreting β-cells in type 2 diabetes (Ritzel  et  al. 2007, Zhao  et...
  6. Research:
    • Penny Ahlstrom,
    • Esther Rai,
    • Suharto Chakma,
    • Hee Ho Cho,
    • Palanivel Rengasamy,
    • and Gary Sweeney
    Adiponectin improves insulin sensitivity via activation of autophagic flux J Mol Endocrinol 59 (4) 339-350, doi: 10.1530/JME-17-0096
    ...of the metabolic syndrome and type 2 diabetes (Marette et al. 2014). New knowledge contributing to our understanding of the mechanisms responsible for development of skeletal muscle insulin resistance is thus of great importance in order to facilitate development of improved therapeutic approaches. Various...
  7. Review:
    • Francesco Maria Egro
    Why is type 1 diabetes increasing? J Mol Endocrinol 51 (1) R1-R13, doi: 10.1530/JME-13-0067 first published on 3 June 2013
    ...production of the autoantibodies IA-2 (IA-2A), insulin autoantibodies (IAAs) and GADAs. In vitro studies on NOD mouse islets have suggested that rotaviruses might induce type 1 diabetes by direct infection of the b-cells. However, human rotaviruses were successful in replication only in monkey islets...
  8. Review:
    • Maggie C Evans and
    • Greg M Anderson
    Neuroendocrine integration of nutritional signals on reproduction J Mol Endocrinol 58 (2) R107-R128, doi: 10.1530/JME-16-0212 first published on 5 January 2017
    ...weight regulation (Belgardt & Bruning 2010)) has also emerged as a key modulator of reproductive function. Clinically, diabetic insulin insufficiency (i.e. type 1 diabetes) in humans is associated with delayed puberty, reduced LH pulsatility and hypothalamic hypogonadism, despite sufficient energy...
  9. Research:
    • Darren S D Martin,
    • Siobhán Leonard,
    • Robert Devine,
    • Clara Redondo,
    • Gemma K Kinsella,
    • Conor J Breen,
    • Victoria McEneaney,
    • Mary F Rooney,
    • Tim S Munsey,
    • Richard K Porter,
    • Asipu Sivaprasadarao,
    • John C Stephens,
    • and John B C Findlay
    Novel mitochondrial complex I inhibitors restore glucose-handling abilities of high-fat fed mice J Mol Endocrinol 56 (3) 261-271, doi: 10.1530/JME-15-0225 first published on 12 January 2016
    ...Research Novel anti-diabetic complex I inhibitors 10.1530/JME-15-0225 d s d martin and others 56 :3 Key Words f type 2 diabetes f metformin f complex I f NADH dehydrogenase f AMPK f insulin resistance f ATP 56:3 Correspondence should be addressed to D S D Martin Email [email protected] Abstract...
  10. Regular papers:
    • Neil W Salter,
    • Sudharsana R Ande,
    • Hoa K Nguyen,
    • B L Grégoire Nyomba,
    • and Suresh Mishra
    Functional characterization of naturally occurring transglutaminase 2 mutants implicated in early-onset type 2 diabetes J Mol Endocrinol 48 (3) 203-216, doi: 10.1530/JME-11-0064 first published on 6 March 2012
    ...known as a ‘protein crosslinking’ function, due to the formation of a g-glutamyl-3-lysine bond between the side chain ofmore than one susceptibility gene (Ji et al. 1997, Zoualisusceptibility locus for non-insulin-dependent type 2 diabetes of the young (MODY), a group of autosomal dominant, single...
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