... FE, Iturriza F, McLean C, Hope J & Lowry PJ 1982 Stimulation of adrenal mitogenesis by N-terminal pro-opiocortin peptides. Nature 297 419–422. (doi:10.1038/297419a0) Estivariz FE, Carino M, Lowry PJ & Jackson S 1988 Further evidence that N-terminal pro-opiomelanocortin peptides are involved in adrenal...

...Correspondence should be addressed to A B Bicknell Email [email protected] Key Words f N-POMC f adrenal f pro-γ-MSH f growth f POMC f HPA axis Abstract The peptide hormones contained within the sequence of proopiomelanocortin (POMC) have diverse roles ranging from pigmentation to regulation of adrenal...

..., characterized by the failure of the adrenal cortex to produce GC, was first shown to be caused by loss-of-function mutations in MC2R. After the discovery of the causative role of MRAP1 in FDG, more recent studies also identified another protein from the same family, MRAP2, which seems to be linked to obesity...

...accessory proteins (MRAPs). The discovery of MRAP An intact pituitary–adrenal axis is essential for normal healthy existence in mammals, and yet, is surprisingly dependent on a number of unique components encoded by single genes such as the proopiomelanocortin gene and the receptor for adrenocorticotropin...

...:10.1113/jphysiol.2008.153817) Bergen HT, Mizuno T, Taylor J & Mobbs CV 1999 Resistance to dietinduced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus. Brain Research 851 198–203. (doi:10.1016/S0006-8993(99)02186-1) Boudina S, Sena S...

...of the hypothalamus, ↓↓ food intake, ↓ body weight, complete ablation results in starvation and death Gropp et al. (2005), Luquet et al. (2005), Wu et al. (2008a,b) POMC−/− Hyperphagic, ↓ energy expenditure, adrenal insufficiency, develop obesity exacerbated with high-fat diet, lighter than littermates-colored dorsal...

[email protected] Abstract The evolution of the melanocortin receptors (MCRs) is linked to the evolution of adrenocorticotrophic hormone (ACTH), the melanocyte-stimulating hormones (MSHs), and their common precursor pro-opiomelanocortin (POMC). The origin of the MCRs and POMC appears to be grounded in the early radiation...

...Biotechnology and College of Life Science, Nanjing Normal University, Nanjing, China) Abstract miR-132 is hormonally regulated in steroidogenic cells of the adrenal gland, ovary and testis. Here, we examined the potential role of miR-132 in the control of steroidogenesis. Transfection of Y1 adrenal cells...

...ovary syndrome (PCOS) is the most common cause of anovulatory infertility in reproductive-aged women affecting 12–18% of women (March et al. 2010). It is a reproductive, metabolic and psychological condition underpinned by genetic abnormalities and exacerbated by obesity. Its key pathophysiological...