Searching journal content for articles similar to Rastinejad et al. 51 (3): T1.

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  1. Review:
    • Tram B Doan,
    • J Dinny Graham,
    • and Christine L Clarke
    Emerging functional roles of nuclear receptors in breast cancer J Mol Endocrinol 58 (3) R169-R190, doi: 10.1530/JME-16-0082 first published on 13 January 2017
    ...of NRs made possible through advances in genomic technologies. The nuclear receptor superfamily The human nuclear receptor superfamily consists of 48 members. These transcription factors include the receptors for steroid hormones, thyroid hormones, lipophilic vitamins and cholesterol metabolites...
  2. Review:
    • Kyle T Helzer,
    • Christopher Hooper,
    • Shigeki Miyamoto,
    • and Elaine T Alarid
    Ubiquitylation of nuclear receptors: new linkages and therapeutic implications J Mol Endocrinol 54 (3) R151-R167, doi: 10.1530/JME-14-0308 first published on 5 May 2015
    ...of nuclear receptor signaling Nuclear receptors (NRs) comprise a family of transcriptional regulators that control multiple physiological estradiol (E2) (Toft & Gorski 1966, Jensen et al. 1967). X receptor (RXR, NR2B1–3), vitamin D receptor (VDR, NR1I1), peroxisomeproliferato tivation domain, a central DNA...
  3. Review:
    • Raffaella Maria Gadaleta and
    • Luca Magnani
    Nuclear receptors and chromatin: an inducible couple J Mol Endocrinol 52 (2) R137-R149, doi: 10.1530/JME-13-0170 first published on 20 December 2013
    ...,transcriptional machinery. Introduction/overview Nuclear receptors (NRs) are evolutionarily related DNAbinding transcription factors (TFs) (Gronemeyer et al. 2004, Chambon 2005, Evans 2005). They regulate many establishment as drug tar conditions. Currently, 13% target NRs (Overington es for several pathological f all FDA...
  4. Thematic Review:
    • Weiwei Fan,
    • Annette R Atkins,
    • Ruth T Yu,
    • Michael Downes,
    • and Ronald M Evans
    Road to exercise mimetics: targeting nuclear receptors in skeletal muscle J Mol Endocrinol 51 (3) T87-T100, doi: 10.1530/JME-13-0258
    ...known for its health benefits since 1990). Upon insulin stimulation, skeletal muscle can bemetabolic syndrome and cancer. Nuclear receptors (NRs) comprise a class of transcription factors found only in metazoans that regulate major biological processes such as reproduction, development, and metabolism...
  5. Thematic Review:
    • Shannon E Mullican,
    • Joanna R DiSpirito,
    • and Mitchell A Lazar
    The orphan nuclear receptors at their 25-year reunion J Mol Endocrinol 51 (3) T115-T140, doi: 10.1530/JME-13-0212 first published on 4 October 2013
    ...that the steroid hormone receptors shared highly conserved domains encouraged researchers to search for additional members of the nuclear receptor (NR) family (Mangelsdorf et al. 1995, Giguère 1999, Willson & Moore 2002, Benoit et al. 2006). conserved within orphan the DBD to the carboxy-ter (LBD) is the hinge...
  6. Review:
    • Subhamoy Dasgupta and
    • Bert W O'Malley
    Transcriptional coregulators: emerging roles of SRC family of coactivators in disease pathology J Mol Endocrinol 53 (2) R47-R59, doi: 10.1530/JME-14-0080 first published on 14 July 2014
    ...that coactivators are important for almost all biological functions, and consequently, genetic defects can lead to severe pathologies. Drug discovery " transcription factors " nuclear receptorsTranscriptional coregula emerging roles of SRC fa coactivators in disease p Subhamoy Dasgupta* and Bert W O...
  7. Review:
    • Russell A Prough,
    • Barbara J Clark,
    • and Carolyn M Klinge
    Novel mechanisms for DHEA action J Mol Endocrinol 56 (3) R139-R155, doi: 10.1530/JME-16-0013 first published on 23 February 2016
    ...(reviewed in Maninger et  al. 2009, Traish et  al. 2011, Maggio et  al. 2015). In addition to providing precursors for sex steroids, DHEA binds directly to steroid hormone and nuclear receptors (NRs), activating various membrane receptors and inhibiting voltage-gated T-type Ca2+ channels. This review...
  8. Review:
    • Jaya Nautiyal
    Transcriptional coregulator RIP140: an essential regulator of physiology J Mol Endocrinol 58 (3) R147-R158, doi: 10.1530/JME-16-0156 first published on 10 January 2017
    ...and Developmental Biology, Faculty of Medicine, Imperial College London, London, UK Abstract Transcriptional coregulators drive gene regulatory decisions in the transcriptional space. Although transcription factors including all nuclear receptors provide a docking platform for coregulators to bind, these proteins...
  9. Review:
    • Silvia Ottaviani,
    • Alexander de Giorgio,
    • Victoria Harding,
    • Justin Stebbing,
    • and Leandro Castellano
    Noncoding RNAs and the control of hormonal signaling via nuclear receptor regulation J Mol Endocrinol 53 (2) R61-R70, doi: 10.1530/JME-14-0134 first published on 25 July 2014
    ...(NRs) are ligand-activated transcription factors that regulate gene expression by binding to regulatory regions in the genomic DNA. NRs are critically involved in an array of physiological processes including growth, differentiation, homeostasis, development, and metabolism (Mangelsdorf et al. 1995...
  10. Review:
    • Sylvia C Hewitt,
    • Wipawee Winuthayanon,
    • and Kenneth S Korach
    What's new in estrogen receptor action in the female reproductive tract J Mol Endocrinol 56 (2) R55-R71, doi: 10.1530/JME-15-0254
    ...-dependent and ligand-independent nuclear receptor mechanisms. The direct ‘classic’ model of ER action involves direct interaction between ER bound to estrogen (triangles) and ERE; the tethered pathway utilizes indirect ‘tethering’ of ER to genes via interactions with other transcription factors (TF). ‘Nongenomic...
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