..., but the cellular mechanisms involved have not been addressed. We employed our extensively characterised murine brown adipocyte cells. D1-like and D2-like receptors were detectable at the protein level. Stimulation with DA caused an increase in cAMP concentrations. Oxygen consumption rates (OCR), mitochondrial...

...are markedly decreased (Aguilera et al. 1981), whereas the production of deoxycorticosterone and precursor steroids is conversely increased, indicating a blockade in the late step of aldosterone synthesis (Bird et  al. 1996). These functional changes are accompanied by a morphological transformation of ZG...

...have not been clarified in detail. Characterizing aldosterone (Ald) target genes in adipocytes will help us to elucidate the deleterious effects associated with excess Ald. Apelin, a novel adipokine, exerts beneficial effects on obesityassociated disorders and cardiovascular homeostasis. The objective...

...a few cells, ‘++’ a few areas and ‘+++’ when the section was full of beige adipocytes. Real-time PCR Total RNA was extracted using TRIzol (Invitrogen) and reverse transcribed with an iScript cDNA synthesis kit (BioRad). Quantitative PCR was performed using a SYBR green PCR kit and a ViiA7 RT-PCR system...

...disease. Primary hyperaldosteronism (PA), a cause of secondary hypertension due to chronic excessive aldosterone synthesis, is associated with increased mortality and morbidity independent of the degree of hypertension (Milliez et al. 2005). The MR can change cell function through multiple means. Edelman...

...Endocrinology (2014) 52, 159–167 eswaran et al. 1989, Wei et al. Research S J A FELIZOLA and others PCP4: a regulator of aldosterone synthesis 52 :2 159–167(CaM) (Wei et al. 2011). PCP4 is abundant in Purkinje7.6 kDa protein with an IQ-motif that binds to calmodulin 2011). PCP4- mice were reported...

...Key Words " adipocytes " autophagy " insulin resistance " progranulin " TNFR1 recently emerged as an important regulator of glucose sex- and BMI-matched insulin-sensitive counterparts ng that progranulin can be a nsulin sensitivity and energy ogranulin in adipose tissue in od, its link...

...1. This is a key enzyme in adipocyte differentiation and lipid synthesis. These results support the hypothesis that BPA could stimulate preadipocyte differentiation and adipogenesis and thus promote obesity in childhood. Moreover, molecular studies have demonstrated that a large number of genes...