Searching journal content for insulin secretion (as phrase) in full text.

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  1. Review:
    • Jinghua Peng and
    • Ling He
    IRS posttranslational modifications in regulating insulin signaling J Mol Endocrinol JME-17-0151, doi: 10.1530/JME-17-0151 first published on 1 November 2017
    ...insulin secretion from pancreatic 63 β-cells(Kido, et al. 2000; Tamemoto et al. 1994). Since defective hepatic insulin sensitivity in 64 type 2 diabetes results in increased glucose production, which is the major cause of 65 hyperglycemia in diabetic patients(Kunert, et al. 2003; Magnusson, et al. 1 ~~~
  2. Review:
    • William C Newton,
    • Joseph W Kim,
    • John Z Q Luo,
    • and LuGuang Luo
    Stem cell-derived exosomes: a novel vector for tissue repair and diabetic therapy J Mol Endocrinol 59 (4) R155-R165, doi: 10.1530/JME-17-0080 first published on 23 August 2017
    ...insulin secretion and hyperglycemia. Sufferers of this heritable disorder are often dependent on frequent insulin injections to prevent hyperglycemia, along with other medications to manage T1D’s often debilitating symptoms (Atkinson et  al. 2014, Miller  et  al. 2015). Exosomes derived from stem ce ~~~
  3. Review:
    • Daniel Raleigh,
    • Xiaoxue Zhang,
    • Benoît Hastoy,
    • and Anne Clark
    The β-cell assassin: IAPP cytotoxicity J Mol Endocrinol 59 (3) R121-R140, doi: 10.1530/JME-17-0105 first published on 15 August 2017
    ...insulin secretion in isolated human islets. Diabetes 56 65–71. (doi:10.2337/db06-0734) Rivera JF, Costes S, Gurlo T, Glabe CG & Butler PC 2014 Autophagy defends pancreatic beta cells from human islet amyloid polypeptideinduced toxicity. Journal of Clinical Investigation 124 3489–3500. (doi:10.1172/J ~~~
  4. Research:
    • Dennis Brüning,
    • Kirstin Reckers,
    • Peter Drain,
    • and Ingo Rustenbeck
    Glucose but not KCl diminishes submembrane granule turnover in mouse beta-cells J Mol Endocrinol 59 (3) 311-324, doi: 10.1530/JME-17-0063 first published on 1 August 2017
    ...insulin secretion elicited by KCl is often regarded as the equivalent of the first phase of glucose-induced insulin secretion. Here, the effects of both stimuli were compared by measuring the secretion of perifused mouse islets, the cytosolic Ca2+ concentration of single beta-cells and the mobility ~~~
  5. Review:
    • Alvaro Moreira,
    • Samuel Kahlenberg,
    • and Peter Hornsby
    Therapeutic potential of mesenchymal stem cells for diabetes J Mol Endocrinol 59 (3) R109-R120, doi: 10.1530/JME-17-0117 first published on 24 July 2017
    ...insulin secretion . Diabetes Care 39 149 – 157 . ( doi:10.2337/dc15-0171 ) ↵ Caplan AI & Correa D 2011 The MSC: an injury drugstore . Cell Stem Cell 9 11 – 15 . ( doi:10.1016/j.stem.2011.06.008 ) Carlsson P-O , Schwarcz E , Korsgren O & Le Blanc K 2015 Preserved β-cell function in type 1 dia ~~~
  6. Research:
    • Yu-Guang Ma,
    • Liang Liang,
    • Yin-Bin Zhang,
    • Bao-Feng Wang,
    • Yun-Gang Bai,
    • Zhi-Jun Dai,
    • Man-Jiang Xie,
    • and Zhong-Wei Wang
    Berberine reduced blood pressure and improved vasodilation in diabetic rats J Mol Endocrinol 59 (3) 191-204, doi: 10.1530/JME-17-0014 first published on 17 May 2017
    ...insulin secretion capacity (Zhang et al. 2008). Vascular disease is one of the important factors for the increased risks of stroke, heart attack and organ damage in diabetic patients (Fernández-Velasco  et  al. 2014). Hyperglycemia and hypertension that are considered to be the two hallmark features ~~~
  7. Research:
    • Ting-Ting Zhou,
    • Fei Ma,
    • Xiao-Fan Shi,
    • Xin Xu,
    • Te Du,
    • Xiao-Dan Guo,
    • Gai-Hong Wang,
    • Liang Yu,
    • Vatcharin Rukachaisirikul,
    • Li-Hong Hu,
    • Jing Chen,
    • and Xu Shen
    DMT efficiently inhibits hepatic gluconeogenesis by regulating the Gαq signaling pathway J Mol Endocrinol 59 (2) 151-169, doi: 10.1530/JME-17-0121 first published on 21 June 2017
    ...insulin secretion is inhibited in healthy lean males (Chakravarthy  et  al. 2017), we incubated with glucagon (10 nM) for long time to mimic the pathological state of hyperglucagonemia and stimulate excessive gluconeogenesis in HGP assay. In the assay, sodium lactate (20 mM) and sodium pyruvate (2 m ~~~
  8. Review:
    • Zodwa Dlamini,
    • Fortunate Mokoena,
    • and Rodney Hull
    Abnormalities in alternative splicing in diabetes: therapeutic targets J Mol Endocrinol 59 (2) R93-R107, doi: 10.1530/JME-17-0049
    ...insulin secretion is very similar to neurotransmitter secretion. Some neuron-enriched splicing regulators are also expressed in pancreatic β cells and play a role in regulating β cell survival and function. These include RNA-binding proteins (RBPs) that regulate the splicing of genes and are members ~~~
  9. Research:
    • Chunheng Mo,
    • Long Huang,
    • Lin Cui,
    • Can Lv,
    • Dongliang Lin,
    • Liang Song,
    • Guoqiang Zhu,
    • Juan Li,
    • and Yajun Wang
    Characterization of NMB, GRP and their receptors (BRS3, NMBR and GRPR) in chickens J Mol Endocrinol 59 (1) 61-79, doi: 10.1530/JME-17-0020 first published on 12 May 2017
    ...insulin secretion in mice (Ohki-Hamazaki  et  al. 1997b, Guan  et  al. 2010, Metzger  et  al. 2010), and thus, BRS3 has been viewed as a promising therapeutic target to treat obesity and diabetes in humans (Guan et al. 2010, Majumdar & Weber 2012, Gonzalez et al. 2015). However, unlike NMBR/GRPR, hu ~~~
  10. Review:
    • J Jason Collier,
    • Tim E Sparer,
    • Michael D Karlstad,
    • and Susan J Burke
    Pancreatic islet inflammation: an emerging role for chemokines J Mol Endocrinol 59 (1) R33-R46, doi: 10.1530/JME-17-0042 first published on 18 April 2017
    ...insulin secretion and calcium usage in rodent and human islets associated with T1D and T2D (Boucher et al. 2004, Dula et al. 2010, Ramadan et al. 2011, Do et al. 2014, Burke et al. 2015b, Kenty & Melton 2015, Qureshi  et  al. 2015). Seventh, immune cells infiltrate the islets in both T1D and T2D (Ge ~~~
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