Searching journal content for dimers (as phrase) in full text.

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  1. Research:
    • William J Stanley,
    • Prerak M Trivedi,
    • Andrew P Sutherland,
    • Helen E Thomas,
    • and Esteban N Gurzov
    Differential regulation of pro-inflammatory cytokine signalling by protein tyrosine phosphatases in pancreatic β-cells J Mol Endocrinol 59 (4) 325-337, doi: 10.1530/JME-17-0089 first published on 21 August 2017
    ...dimers translocate to the nucleus and induce gamma-activated site (GAS) gene expression (Moore et  al. 2011), which includes chemokines, BH3-only apoptotic proteins and the major histocompatibility complex (MHC-I), important for diabetes development in the NOD mouse model (Serreze et al. 1994, Hamil ~~~
  2. Review:
    • Daniel Raleigh,
    • Xiaoxue Zhang,
    • Benoît Hastoy,
    • and Anne Clark
    The β-cell assassin: IAPP cytotoxicity J Mol Endocrinol 59 (3) R121-R140, doi: 10.1530/JME-17-0105 first published on 15 August 2017
    ...dimers ~~~
  3. Review:
    • Melanie Sapochnik,
    • Mariana Fuertes,
    • and Eduardo Arzt
    Programmed cell senescence: role of IL-6 in the pituitary J Mol Endocrinol 58 (4) R241-R253, doi: 10.1530/JME-17-0026 first published on 5 April 2017
    ...dimers and STAT3/ STAT1 heterodimers. These activated STAT dimers enter the nucleus and bind to the specific DNA sequences in the regulatory regions of their target genes (Darnell 1997). STAT3 plays multiple roles depending on the cell context. The involvement of STAT3 in proliferation and cell surv ~~~
  4. Research:
    • Alessandra Mingione,
    • Chiara Verdelli,
    • Stefano Ferrero,
    • Valentina Vaira,
    • Vito Guarnieri,
    • Alfredo Scillitani,
    • Leonardo Vicentini,
    • Gianni Balza,
    • Edoardo Beretta,
    • Annalisa Terranegra,
    • Giuseppe Vezzoli,
    • Laura Soldati,
    • and Sabrina Corbetta
    Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors J Mol Endocrinol 58 (2) 91-103, doi: 10.1530/JME-16-0184 first published on 21 November 2016
    ...dimers increase inositol-triphosphate and intracellular calcium concentrations, activate protein kinase C and intracellular calcium oscillations and stimulate mitogen-activated protein kinase (MAPK) cascade through p44/42 extracellular signaling-regulated kinase (ERK) phosphorylation (Breitwieser & ~~~
  5. Review:
    • Gregory S Y Ong and
    • Morag J Young
    Mineralocorticoid regulation of cell function: the role of rapid signalling and gene transcription pathways J Mol Endocrinol 58 (1) R33-R57, doi: 10.1530/JME-15-0318 first published on 7 November 2016
    ...dimers (Nishi  et  al. 2004, Grossmann  et  al. 2012). The MR not only forms homodimers, but also heterodimerises with GR, resulting in different transcriptional responses. The degree of heterodimerisation depends on the relative abundance of activated MR and GR, which is influenced by hormone avail ~~~
  6. Focused Review:
    • Jessica Sabourin and
    • Florent Allagnat
    Store-operated Ca2+ entry: a key component of the insulin secretion machinery J Mol Endocrinol 57 (3) F35-F39, doi: 10.1530/JME-16-0106 first published on 2 September 2016
    ...dimers and translocation to ER/plasmalemmal junctional regions, where they physically interact with store-operated channels (SOCs) to induce SOCE. Despite high homology, the two isoforms, STIM1 and STIM2, have subtly distinct functions. STIM1 seems to be the main SOC-activating isoform, while STIM2, ~~~
  7. Review:
    • Kira Meyerovich,
    • Fernanda Ortis,
    • Florent Allagnat,
    • and Alessandra K Cardozo
    Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation J Mol Endocrinol 57 (1) R1-R17, doi: 10.1530/JME-15-0306 first published on 11 April 2016
    ...dimers to migrate to the nucleus and induce the expression of several cytokines and chemokines (Shih et al. 2011). During ER stress, NF-κB can be induced due to PERK-mediated attenuation of protein translation, leading to decreased levels of IκB proteins and consequent increase of NF-κB (Fig. 1) (De ~~~
  8. Review:
    • Gunnar Kleinau,
    • Anne Müller,
    • and Heike Biebermann
    Oligomerization of GPCRs involved in endocrine regulation J Mol Endocrinol 57 (1) R59-R80, doi: 10.1530/JME-16-0049 first published on 5 May 2016
    ...dimers f oligomers f endocrine regulation f endocrine diseases f signaling Correspondence should be addressed to H Biebermann Email [email protected] Abstract More than 800 different human membrane-spanning G-protein-coupled receptors (GPCRs) serve as signal transducers at biological barri ~~~
  9. Thematic Review:
    • Niamh X Cawley,
    • Zhaojin Li,
    • and Y Peng Loh
    60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides J Mol Endocrinol 56 (4) T77-T97, doi: 10.1530/JME-15-0323 first published on 15 February 2016
    ...dimers and multimers (Cawley et al. 2000), and this aggregation is enhanced in the presence of increased calcium and reduced pH, conditions expected in the TGN (Chandra et  al. 1991, Seksek et  al. 1995). More importantly, the N-POMC(1–26) domain was not required for aggregation, thus allowing it to ~~~
  10. Thematic Review:
    • Jacques Drouin
    60 YEARS OF POMC: Transcriptional and epigenetic regulation of POMC gene expression J Mol Endocrinol 56 (4) T99-T112, doi: 10.1530/JME-15-0289 first published on 20 January 2016
    ...dimers containing the basic helix-loop-helix (bHLH) factor neurogenic differentiation 1 (NeuroD1) (Poulin et al. 1997) as well as a binding site for orphan nuclear receptors (NR) of the Nur subfamily (Philips et al. 1997a). Thus, these two cell-specific regulatory elements, the Pitx/Tpit and NeuroD1 ~~~
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