Searching journal content for PPARs (as phrase) in full text.

Displaying results 1-10 of 45
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  1. Review:
    • Zodwa Dlamini,
    • Fortunate Mokoena,
    • and Rodney Hull
    Abnormalities in alternative splicing in diabetes: therapeutic targets J Mol Endocrinol 59 (2) R93-R107, doi: 10.1530/JME-17-0049
    ...PPARs (peroxisome proliferator-activated receptors) and increase the uptake of glucose by binding to PPARS a group of receptor molecules inside the cell nucleus, specifically PPAR(gamma) (Kahn et al. 2000). FFAs and eicosanoids serve as ligands for PPAR receptors. When activated the ligands migrate ~~~
  2. Review:
    • Marcel J M Schaaf
    Nuclear receptor research in zebrafish J Mol Endocrinol 59 (1) R65-R76, doi: 10.1530/JME-17-0031 first published on 24 April 2017
    ...PPARs are NRs which are activated by dietary lipids including saturated and unsaturated fatty acids, and by lipids involved in intracellular signaling pathways like prostaglandins and leukotrienes. By binding these ligands, they play an important physiological role as lipid sensors regulating energy ~~~
  3. Research:
    • Yueting Dong,
    • Zhiye Xu,
    • Ziyi Zhang,
    • Xueyao Yin,
    • Xihua Lin,
    • Hong Li,
    • and Fenping Zheng
    Impaired adipose expansion caused by liver X receptor activation is associated with insulin resistance in mice fed a high-fat diet J Mol Endocrinol 58 (3) 141-154, doi: 10.1530/JME-16-0196
    ...PPARs and sometimes competes for the same DNA response elements suggests that LXR could affect PPAR signalling (Ide et al. 2003, Yoshikawa et al. 2003). Impaired adipose expansion was generally associated with ectopic lipid accumulation and insulin resistance. Indeed in the present study, moderate h ~~~
  4. Review:
    • Tram B Doan,
    • J Dinny Graham,
    • and Christine L Clarke
    Emerging functional roles of nuclear receptors in breast cancer J Mol Endocrinol 58 (3) R169-R190, doi: 10.1530/JME-16-0082 first published on 13 January 2017
    ...PPARs function as heterodimers with the retinoid receptors (RXR) and regulate various genes that are involved in lipid metabolism and energy homeostasis. Through these pathways, PPARs influence various cancer-related cellular processes such as proliferation, differentiation and survival (Michalik et ~~~
  5. Research:
    • Sushi Jiang,
    • Hening Zhai,
    • Danjie Li,
    • Jiana Huang,
    • Heng Zhang,
    • Ziru Li,
    • Weizhen Zhang,
    • and Geyang Xu
    AMPK-dependent regulation of GLP1 expression in L-like cells J Mol Endocrinol 57 (3) 151-160, doi: 10.1530/JME-16-0099 first published on 4 August 2016
    ...PPARs ~~~
  6. Research:
    • Kent Wehmeier,
    • Luisa M Onstead-Haas,
    • Norman C W Wong,
    • Arshag D Mooradian,
    • and Michael J Haas
    Pro-inflammatory signaling by 24,25-dihydroxyvitamin D3 in HepG2 cells J Mol Endocrinol 57 (2) 87-96, doi: 10.1530/JME-16-0009 first published on 27 May 2016
    ...PPARs or the bile acid receptor farnesoid-X receptor (FXR) (Vu-Dac et  al. 1998, Sakamoto et al. 2000, Claudel et al. 2002). However, it is possible that 24,25-[OH]2D3 down-regulates the expression of various nuclear receptors that regulate lipid and cholesterol metabolism. Therefore, we investigate ~~~
  7. Review:
    • Christopher E Wall,
    • Ruth T Yu,
    • Anne R Atkins,
    • Michael Downes,
    • and Ronald M Evans
    Nuclear receptors and AMPK: can exercise mimetics cure diabetes? J Mol Endocrinol 57 (1) R49-R58, doi: 10.1530/JME-16-0073 first published on 22 April 2016
    ...PPARs f AMPK f PGC1α f sirtuins f exercise mimetics f diabetes Correspondence should be addressed to R M Evans Email [email protected] Abstract Endurance exercise can lead to systemic improvements in insulin sensitivity and metabolic homeostasis, and is an effective approach to combat metabolic disease ~~~
  8. Review:
    • Inna Astapova
    Role of co-regulators in metabolic and transcriptional actions of thyroid hormone J Mol Endocrinol 56 (3) R73-R97, doi: 10.1530/JME-15-0246 first published on 16 December 2015
    ...PPARs (Fang et al. 2010, Reilly et al. 2010). As the CoRs are thought to exert much of their repressive actions by recruiting and activating HDAC3 (Guenther et al. 2001), mice bearing inactivating mutation in DAD of NCoR (N-DADm) and SMRT (S-DADm) were also generated and characterized (Alenghat et a ~~~
  9. Review:
    • Russell A Prough,
    • Barbara J Clark,
    • and Carolyn M Klinge
    Novel mechanisms for DHEA action J Mol Endocrinol 56 (3) R139-R155, doi: 10.1530/JME-16-0013 first published on 23 February 2016
    ...PPARs A number of the hepatic NRs, PPARα, constitutive androstane receptor (CAR), and PXR, that regulate the transcription of CYP genes and other foreign compoundmetabolizing enzymes are regulated by sterols such as DHEA, as initially reviewed by Webb and coworkers (Webb et al. 2006). Interest in DH ~~~
  10. Research:
    • Kristine M Wadosky,
    • Jessica M Berthiaume,
    • Wei Tang,
    • Makhosi Zungu,
    • Michael A Portman,
    • A Martin Gerdes,
    • and Monte S Willis
    MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo J Mol Endocrinol 56 (3) 273-290, doi: 10.1530/JME-15-0283 first published on 9 February 2016
    ...PPARs ~~~
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