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  1. ...H6PDH f 11β-HSD1 inhibitor f cardiomyocyte f fibroblast f macrophage f myocardial infarction f heart failure Introduction The major physiological adrenocorticosteroid hor­ mones, glucocorticoids (cortisol in most animals and corticosterone in rats and mice) and mineralocorticoids (aldosterone) are v ~~~
  2. ...H6PDH in both male db/C and db/db mouse liver tissue. We observed that G6PT ASO Journal of Molecular Endocrinology (2013) 50, 167–178 Research H DU, L LIU and others The impact of G6PT on H6PDH and 11b-HSD1 50 :2 167–178prevalence worldwide emphasizing the urgent need forObesity and type 2 diabetes ~~~
  3. ...H6PDH in vivo and in vitro in hepatocytes. Treatment of DIO mice with CBX markedly reduced hepatic GR mRNA levels and reduced weight gain, hyperglycemia, and insulin resistance. The reduction of hepatic GR gene expression was accompanied by CBX-induced inhibition of both 11b-HSD1 and H6PDH activity ~~~
  4. ...H6PDH expression may be an important determinant of 11#1;-HSD1 oxo-reductase activity. Transient transfection of chinese hamster ovary (CHO) cells with 11#1;-HSD1 resulted in the appearance of both oxo-reductase and dehydrogenase activities in intact cells. Co-transfection of 11#1;-HSD1 with H6PDH i ~~~
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