Searching journal content for GPCR (as phrase) in full text.

Displaying results 1-10 of 92
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  1. Research:
    • Ting-Ting Zhou,
    • Fei Ma,
    • Xiao-Fan Shi,
    • Xin Xu,
    • Te Du,
    • Xiao-Dan Guo,
    • Gai-Hong Wang,
    • Liang Yu,
    • Vatcharin Rukachaisirikul,
    • Li-Hong Hu,
    • Jing Chen,
    • and Xu Shen
    DMT efficiently inhibits hepatic gluconeogenesis by regulating the Gαq signaling pathway J Mol Endocrinol 59 (2) 151-169, doi: 10.1530/JME-17-0121 first published on 21 June 2017
    ...of Chinese Medicine, Nanjing, China Abstract Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with complicated pathogenesis and targeting gluconeogenesis inhibition is a promising strategy for antidiabetic drug discovery. G protein-coupled receptors (GPCRs) are classified as distinct families ~~~
  2. Research:
    • Chunheng Mo,
    • Long Huang,
    • Lin Cui,
    • Can Lv,
    • Dongliang Lin,
    • Liang Song,
    • Guoqiang Zhu,
    • Juan Li,
    • and Yajun Wang
    Characterization of NMB, GRP and their receptors (BRS3, NMBR and GRPR) in chickens J Mol Endocrinol 59 (1) 61-79, doi: 10.1530/JME-17-0020 first published on 12 May 2017
    ...protein-coupled receptor (GPCR) and are functionally coupled to Gq protein (Benyaetal. 1995, Jensenetal. 2008). Upon ligand stimulation, both receptors can trigger multiple signaling pathways, such as calcium mobilization and activation of MAPK/ERK signaling cascade (Jensen et al. 2008 ~~~
  3. Review:
    • J Jason Collier,
    • Tim E Sparer,
    • Michael D Karlstad,
    • and Susan J Burke
    Pancreatic islet inflammation: an emerging role for chemokines J Mol Endocrinol 59 (1) R33-R46, doi: 10.1530/JME-17-0042 first published on 18 April 2017
    ...and resolution of various disease processes constitute active research areas. Chemokines are protein ligands for their cognate chemokine receptors, which are members of the much larger G protein coupled receptor (GPCR) superfamily. Upon ligand binding to the chemokine receptor, a conformational change leads ~~~
  4. Focused Review:
    • Adrian J L Clark and
    • Li F Chan
    Promiscuity among the MRAPs J Mol Endocrinol 58 (3) F1-F4, doi: 10.1530/JME-17-0002 first published on 17 February 2017
    ...to develop new and better drugs, many of which will be targeted at G protein-coupled receptors (GPCRs). Massive small molecule library screening requires the availability of a target that most closely resembles the physiological target, and yet, our understanding of the subtle regulatory factors that may ~~~
  5. Review:
    • Eva Tudurí,
    • Monica Imbernon,
    • Rene Javier Hernández-Bautista,
    • Marta Tojo,
    • Johan Fernø,
    • Carlos Diéguez,
    • and Rubén Nogueiras
    GPR55: a new promising target for metabolism? J Mol Endocrinol 58 (3) R191-R202, doi: 10.1530/JME-16-0253 first published on 14 February 2017
    ..., CIMUS, University of Santiago de Compostela, Santiago de Compostela,Spain 4Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen,Norway Abstract GPR55 is a G-protein-coupled receptor (GPCR) that has been identified as a new cannabinoid receptor. Given ~~~
  6. Research:
    • Ricardo Núñez Miguel,
    • Jane Sanders,
    • Jadwiga Furmaniak,
    • and Bernard Rees Smith
    Glycosylation pattern analysis of glycoprotein hormones and their receptors J Mol Endocrinol 58 (1) 25-41, doi: 10.1530/JME-16-0169 first published on 14 November 2016
    ...) belongs to the glycoprotein hormone receptor (GPHR) subfamily of the leucine-rich repeat-containing family of the class A GPCRs (Hsuetal. 2000). GPHRs are characterised by a large amino-terminal extracellular domain (ECD), which forms the high-affinity binding site for their cognate hormones (Nagayama ~~~
  7. Research:
    • Benjamin Kalbe,
    • Marian Schlimm,
    • Julia Mohrhardt,
    • Paul Scholz,
    • Fabian Jansen,
    • Hanns Hatt,
    • and Sabrina Osterloh
    Helional induces Ca2+ decrease and serotonin secretion of QGP-1 cells via a PKG-mediated pathway J Mol Endocrinol 57 (3) 201-210, doi: 10.1530/JME-16-0063 first published on 23 August 2016
    ...), in which they regulate important physiological processes, such as proliferation or migration. ORs constitute a supergene family within the class of Gprotein-coupled receptors (GPCRs) and are activated by specific odorants. In the olfactory sensory neurons (OSNs), a conformational change ~~~
  8. Review:
    • Fadil M Hannan,
    • Valerie N Babinsky,
    • and Rajesh V Thakker
    Disorders of the calcium-sensing receptor and partner proteins: insights into the molecular basis of calcium homeostasis J Mol Endocrinol 57 (3) R127-R142, doi: 10.1530/JME-16-0124
    ...tissues such as the parathyroid glands and kidneys. These studies also revealed the involvement of a G protein-coupled receptor (GPCR) pathway that comprises the calcium-sensing receptor (CaSR), G-protein -11 (G11) subunit and adaptor-related protein complex 2 sigma (AP2) subunit (Pollak etal. 1993 ~~~
    OPEN ACCESS ARTICLE
  9. Review:
    • Haihua Yang and
    • Linghai Yang
    Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy J Mol Endocrinol 57 (2) R93-R108, doi: 10.1530/JME-15-0316 first published on 18 May 2016
    ...monophosphate (cAMP) is an intracellular second messenger that is usually elicited by binding of hormones and neurotransmitters to G protein-coupled receptors (GPCRs). cAMP exerts many of its physiological effects by activating cAMPdependent protein kinase (PKA), which in turn phosphorylates and regulates ~~~
  10. Research:
    • Giampaolo Trivellin,
    • Ivana Bjelobaba,
    • Adrian F Daly,
    • Darwin O Larco,
    • Leonor Palmeira,
    • Fabio R Faucz,
    • Albert Thiry,
    • Letícia F Leal,
    • Liliya Rostomyan,
    • Martha Quezado,
    • Marie Helene Schernthaner-Reiter,
    • Marija M Janjic,
    • Chiara Villa,
    • T John Wu,
    • Stanko S Stojilkovic,
    • Albert Beckers,
    • Benjamin Feldman,
    • and Constantine A Stratakis
    Characterization of GPR101 transcript structure and expression patterns J Mol Endocrinol 57 (2) 97-111, doi: 10.1530/JME-16-0045 first published on 9 June 2016
    .../or hyperplasia before 5 years of age (Beckers et al. 2015). We have previously shown that the smallest common duplicated region shared by all patients is about 500 kb long and contains four OMIM genes, of which only an orphan G protein-coupled receptor (GPCR) named GPR101 (OMIM# 300393) is highly expressed ~~~
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