-
Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse
classes of RORγt inhibitors
Xiang Li, Marie Anderson, Delphine Collin, Ingo Muegge, John Wan, Debra Brennan, Stanley Kugler, Donna Terenzio, Charles Kennedy,
Siqi Lin, Mark E. Labadia, Brian Cook, Robert Hughes, and Neil A. Farrow
Journal of Biological Chemistry
(2017)
292 :11618
-
Development of Stabilized Peptide-Based PROTACs against Estrogen Receptor α
Yanhong Jiang, Qiwen Deng, Hui Zhao, Mingsheng Xie, Longjian Chen, Feng Yin, Xuan Qin, Weihao Zheng, Yongjuan Zhao, and Zigang
Li
ACS Chemical Biology
(2018)
13 :628
-
Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in a mouse model of Graves' disease
Hu Cai, Zhe Wang, Hai-qing Zhang, Fu-rong Wang, Chun-xiao Yu, Feng-xia Zhang, Ling Gao, Jian Zhang, and Jia-jun Zhao
Acta Pharmacologica Sinica
(2014)
35 :65
-
RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev–Rev response element complex
Bhargavi Jayaraman, David C Crosby, Christina Homer, Isabel Ribeiro, David Mavor, and Alan D Frankel
eLife
(2014)
3 :
-
Apo- and Antagonist-Binding Structures of Vitamin D Receptor Ligand-Binding Domain Revealed by Hybrid Approach Combining Small-Angle
X-ray Scattering and Molecular Dynamics
Yasuaki Anami, Nobutaka Shimizu, Toru Ekimoto, Daichi Egawa, Toshimasa Itoh, Mitsunori Ikeguchi, and Keiko Yamamoto
Journal of Medicinal Chemistry
(2016)
59 :7888
-
Cellular and Biophysical Pipeline for the Screening of Peroxisome Proliferator-Activated Receptor Beta/Delta Agonists: Avoiding
False Positives
Natália Bernardi Videira, Fernanda Aparecida Heleno Batista, Artur Torres Cordeiro, and Ana Carolina Migliorini Figueira
PPAR Research
(2018)
2018 :1
-
Retinoic Acid Actions through Mammalian Nuclear Receptors
Pengxiang Huang, Vikas Chandra, and Fraydoon Rastinejad
Chemical Reviews
(2014)
114 :233
-
Structure of the homodimeric androgen receptor ligand-binding domain
Marta Nadal, Stefan Prekovic, Nerea Gallastegui, Christine Helsen, Montserrat Abella, Karolina Zielinska, Marina Gay, Marta
Vilaseca, Marta Taulès, Adriaan B. Houtsmuller, Martin E. van Royen, Frank Claessens, Pablo Fuentes-Prior, and Eva Estébanez-Perpiñá
Nature Communications
(2017)
8 :14388
-
Allosteric role of the amino-terminal A/B domain on corticosteroid transactivation of gar and human glucocorticoid receptors
Kaori Oka, Andree Hoang, Daijiro Okada, Taisen Iguchi, Michael E. Baker, and Yoshinao Katsu
The Journal of Steroid Biochemistry and Molecular Biology
(2015)
154 :112
-
Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor
Kareem Mohideen-Abdul, Karima Tazibt, Maxime Bourguet, Isabelle Hazemann, Isabelle Lebars, Maria Takacs, Sarah Cianférani,
Bruno P. Klaholz, Dino Moras, and Isabelle M. L. Billas
Frontiers in Endocrinology
(2017)
8 :
-
Treatment-induced changes in the androgen receptor axis: Liquid biopsies as diagnostic/prognostic tools for prostate cancer
S. Prekovic, T. Van den Broeck, L. Moris, E. Smeets, F. Claessens, S. Joniau, C. Helsen, and G. Attard
Molecular and Cellular Endocrinology
(2018)
462 :56
-
The Nuclear Receptor Field: A Historical Overview and Future Challenges
Gisela I. Mazaira, Nadia R. Zgajnar, Cecilia M. Lotufo, Cristina Daneri-Becerra, Jeffrey C. Sivils, Olga B. Soto, Marc B.
Cox, and Mario D. Galigniana
Nuclear Receptor Research
(2018)
5 :
-
Nuclear receptor full-length architectures: confronting myth and illusion with high resolution
Fraydoon Rastinejad, Vincent Ollendorff, and Igor Polikarpov
Trends in Biochemical Sciences
(2015)
40 :16
-
Structures of PPARγ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic
drugs
Min A Lee, Lingchen Tan, Huiseon Yang, Yeong-Gwan Im, and Young Jun Im
Scientific Reports
(2017)
7 :
-
Discovery of oxa -sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME
properties
Olivier René, Benjamin P. Fauber, Adrian Barnard, Kerry Chapman, Yuzhong Deng, Céline Eidenschenk, Christine Everett, Alberto
Gobbi, Adam R. Johnson, Hank La, Maxine Norman, Gary Salmon, Susan Summerhill, and Harvey Wong
Bioorganic & Medicinal Chemistry Letters
(2016)
26 :4455
-
Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency
Weili Zheng, Lin Qiu, Rui Wang, Xuhui Feng, Yaping Han, Yanlin Zhu, Dezhou Chen, Yijie Liu, Lihua Jin, and Yong Li
Scientific Reports
(2015)
5 :
-
Evolution of human, chicken, alligator, frog, and zebrafish mineralocorticoid receptors: Allosteric influence on steroid specificity
Yoshinao Katsu, Kaori Oka, and Michael E. Baker
Science Signaling
(2018)
11 :eaao1520
-
Advances in our structural understanding of orphan nuclear receptors
Nerea Gallastegui, Jonathan A.G. Mackinnon, Robert J. Fletterick, and Eva Estébanez-Perpiñá
Trends in Biochemical Sciences
(2015)
40 :25
-
Response to Moras et al.
Fraydoon Rastinejad, Vincent Ollendorff, and Igor Polikarpov
Trends in Biochemical Sciences
(2015)
40 :290
-
Detection of marine microalgal biotoxins using bioassays based on functional expression of tunicate xenobiotic receptors in
yeast
Ingrid Richter and Andrew E. Fidler
Toxicon
(2015)
95 :13
-
Investigation of Interactions between DNA and Nuclear Receptors: A Review of the Most Used Methods
Juliana Fattori, Nathalia de Carvalho Indolfo, Jéssica Christina Lóis de Oliveira Campos, Natália Bernardi Videira, Aline
Villanova Bridi, Tábata Renée Doratioto, Michelle Alexandrino de Assis, and Ana Carolina Migliorini Figueira
Nuclear Receptor Research
(2014)
1 :1
-
Crystal Structure of the Mineralocorticoid Receptor DNA Binding Domain in Complex with DNA
William H. Hudson, Christine Youn, Eric A. Ortlund, and Jan Peter Tuckermann
PLoS ONE
(2014)
9 :e107000
-
Signaling through retinoic acid receptors in cardiac development: Doing the right things at the right times
José Xavier-Neto, Ângela M. Sousa Costa, Ana Carolina M. Figueira, Carlo Donato Caiaffa, Fabio Neves do Amaral, Lara Maldanis
Cerqueira Peres, Bárbara Santos Pires da Silva, Luana Nunes Santos, Alexander R. Moise, and Hozana Andrade Castillo
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
(2015)
1849 :94
-
Zearalenone and 17 β-estradiol induced damages in male rats reproduction potential; evidence for ERα and ERβ receptors expression
and steroidogenesis
Elmira Adibnia, Mazdak Razi, and Hassan Malekinejad
Toxicon
(2016)
120 :133
-
The vitamin D receptor (VDR) binds to the nuclear matrix via its hinge domain: A potential mechanism for the reduction in
VDR mediated transcription in mitotic cells
Xiaoying Cui, Renata Pertile, and Darryl W. Eyles
Molecular and Cellular Endocrinology
(2018)
472 :18
-
Profiling of 3696 Nuclear Receptor–Coregulator Interactions: A Resource for Biological and Clinical Discovery
Marjoleine F Broekema, Danielle A A Hollman, Arjen Koppen, Henk-Jan van den Ham, Diana Melchers, Dirk Pijnenburg, Rob Ruijtenbeek,
Saskia W C van Mil, René Houtman, and Eric Kalkhoven
Endocrinology
(2018)
159 :2397
-
Binding characterization, synthesis and biological evaluation of RXRα antagonists targeting the coactivator binding site
Dingyu Xu, Shangjie Guo, Ziwen Chen, Yuzhou Bao, Fengyu Huang, Dan Xu, Xindao Zhang, Zhiping Zeng, Hu Zhou, Xiaokun Zhang,
and Ying Su
Bioorganic & Medicinal Chemistry Letters
(2016)
26 :3846
-
Role of Pro-637 and Gln-642 in human glucocorticoid receptors and Ser-843 and Leu-848 in mineralocorticoid receptors in their
differential responses to cortisol and aldosterone
Orlando Mani, Lyubomir G. Nashev, Christopher Livelo, Michael E. Baker, and Alex Odermatt
The Journal of Steroid Biochemistry and Molecular Biology
(2016)
159 :31
-
Unique oestrogen receptor ligand-binding domain sequence of native parrots: a possible link between phytoestrogens and breeding
success
Catherine E. J. Davis, Adrian H. Bibby, Kevin M. Buckley, Kenneth P. McNatty, and Janet L. Pitman
Reproduction, Fertility and Development
(2018)
30 :262
-
A current structural perspective on PXR and CAR in drug metabolism
Cameron D. Buchman, Sergio C. Chai, and Taosheng Chen
Expert Opinion on Drug Metabolism & Toxicology
(2018)
14 :635
-
Reversing thyroid-hormone-mediated repression of a HSV-1 promoter via computationally guided mutagenesis
Robert W. Figliozzi, Feng Chen, and Shaochung V. Hsia
Journal of Cell Science
(2017)
130 :3740
-
Structure-Based Understanding of Binding Affinity and Mode of Estrogen Receptor α Agonists and Antagonists
Sehan Lee, Mace G. Barron, and Yang Zhang
PLOS ONE
(2017)
12 :e0169607
-
Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA
Ian Mitchelle S. de Vera, Jie Zheng, Scott Novick, Jinsai Shang, Travis S. Hughes, Richard Brust, Paola Munoz-Tello, William
J. Gardner, David P. Marciano, Xiangming Kong, Patrick R. Griffin, and Douglas J. Kojetin
Structure
(2017)
25 :1506
-
Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ)
are disrupted by retinal disease-associated mutations
Joel Fulton, Bismoy Mazumder, Jonathan B Whitchurch, Cintia J Monteiro, Hilary M Collins, Chun M Chan, Maria P Clemente, Miguel
Hernandez-Quiles, Elizabeth A Stewart, Winfried M Amoaku, Paula M Moran, Nigel P Mongan, Jenny L Persson, Simak Ali, and David
M Heery
Cell Death & Disease
(2017)
8 :e2677
-
Evolution of corticosteroid specificity for human, chicken, alligator and frog glucocorticoid receptors
Yoshinao Katsu, Satomi Kohno, Kaori Oka, and Michael E. Baker
Steroids
(2016)
113 :38
-
Cardiac nuclear receptors: architects of mitochondrial structure and function
Rick B. Vega and Daniel P. Kelly
Journal of Clinical Investigation
(2017)
127 :1155
-
A structural perspective on nuclear receptors as targets of environmental compounds
Vanessa Delfosse, Albane le Maire, Patrick Balaguer, and William Bourguet
Acta Pharmacologica Sinica
(2015)
36 :88
-
Comparing the rules of engagement of androgen and glucocorticoid receptors
Frank Claessens, Steven Joniau, and Christine Helsen
Cellular and Molecular Life Sciences
(2017)
74 :2217
-
Journal of Molecular Endocrinology 25th anniversary special issue
R. M. Evans
Journal of Molecular Endocrinology
(2013)
51 :E1
-
Stereocontrolled synthesis of ( S )-9- cis - and ( S )-11- cis -13,14-dihydroretinoic acid
Belén Vaz, Rosana Alvarez, and Angel R. de Lera
Tetrahedron
(2016)
72 :3898
-
Critical Roles of microRNAs in the Pathogenesis of Fatty Liver: New Advances, Challenges, and Potential Directions
Chenggui Miao, Zhongwen Xie, and Jun Chang
Biochemical Genetics
(2018)
:
-
Novel peroxisome proliferator-activated receptor gamma mutation in a family with familial partial lipodystrophy type 3
Konstanze Miehle, Joseph Porrmann, Diana Mitter, Michael Stumvoll, Christiane Glaser, Mathias Fasshauer, and Katrin Hoffmann
Clinical Endocrinology
(2016)
84 :141
-
A ligand-entry surface of the nuclear receptor superfamily consists of the helix H3 of the ligand-binding domain
Motonori Tsuji
Journal of Molecular Graphics and Modelling
(2015)
62 :262
-
The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
Vikas Chandra, Dalei Wu, Sheng Li, Nalini Potluri, Youngchang Kim, and Fraydoon Rastinejad
Nature Communications
(2017)
8 :
-
Crosslinked Aspartic Acids as Helix-Nucleating Templates
Hui Zhao, Qi-Song Liu, Hao Geng, Yuan Tian, Min Cheng, Yan-Hong Jiang, Ming-Sheng Xie, Xiao-Gang Niu, Fan Jiang, Ya-Ou Zhang,
Yuan-Zhi Lao, Yun-Dong Wu, Nai-Han Xu, and Zi-Gang Li
Angewandte Chemie International Edition
(2016)
55 :12088
-
Molecular mechanism of estrogen-estrogen receptor signaling
Pelin Yaşar, Gamze Ayaz, Sırma Damla User, Gizem Güpür, and Mesut Muyan
Reproductive Medicine and Biology
(2017)
16 :4
-
Allosteric pathways in nuclear receptors — Potential targets for drug design
Elias J. Fernandez
Pharmacology & Therapeutics
(2018)
183 :152
-
Crosslinked Aspartic Acids as Helix-Nucleating Templates
Hui Zhao, Qi-Song Liu, Hao Geng, Yuan Tian, Min Cheng, Yan-Hong Jiang, Ming-Sheng Xie, Xiao-Gang Niu, Fan Jiang, Ya-Ou Zhang,
Yuan-Zhi Lao, Yun-Dong Wu, Nai-Han Xu, and Zi-Gang Li
Angewandte Chemie
(2016)
128 :12267
