Coactivator binding to the surface of the LBD. (A) Shown is the RORβ LBD structure with an agonist ligand (blue) that places helix-12 (H12) in the active conformation. From this position, H12 fosters the interactions of an LXXLL motif contained in most p160 coactivators with the surface of the LBD. The LXXLL motif forms a small helical segment, allowing the leucines along one face to firmly dig into a hydrophobic groove on the surface of the LBD. The X residues in the coactivator motif are typically polar and interact with the solvent. Notice that the ligand (blue) is shielded from solvent when H12 is in the active conformation.
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Figure 6
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J Mol Endocrinol December 1, 2013 vol. 51 no. 3 T1-T21
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