Figure 11
Crystal structures of multi domain NR complexes. On the left side is the PPARγ–RXRα complex on DR1 and on the right side is the HNF-4α homodimer on DR1. RXR is indicated in blue and PPAR is indicated in red. The upstream subunit of HNF-4α is indicated in yellow and the downstream subunit is indicated in orange. The green arrows show the direction of the AGGTCA direct repeats in the DR1 response elements in the lower panel for both complexes. Three views of each complex are shown.
