Frank Driessler; Paul A Baldock

Figure 1

Model of leptin and serotonin signaling in the regulation of bone and fat formation. Leptin modulates bone mass through receptors (ObRb) in the brainstem, which stimulate serotonergic neurons. Subsequent serotonin binding to HTR2C receptors on VMH neurons alters bone mass, and HTR1A and 2B receptors on ARC neurons alter appetite. The activity of ObRb in these nuclei is an open question.

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This Article

Published online before print July 26, 2010, doi: 10.1677/JME-10-0015 J Mol Endocrinol October 1, 2010 vol. 45 no. 4 175-181

[1] ↵

Ahn JD,

Dubern B,

Lubrano-Berthelier C,

Clement K &

Karsenty G

2006 Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency. Endocrinology 147 3196–3202.doi:10.1210/en.2006-0281.

[2] Ahn JD,

[3] Dubern B,

[4] Lubrano-Berthelier C,

[5] Clement K &

[6] Karsenty G

[7] ↵

Allison SJ,

Baldock P,

Sainsbury A,

Enriquez R,

Lee NJ,

Lin EJ,

Klugmann M,

During M,

Eisman JA,

Li M

et al.

2006 Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice. Journal of Biological Chemistry 281 23436–23444.doi:10.1074/jbc.M604839200.

[8] Allison SJ,

[9] Baldock P,

[10] Sainsbury A,

[11] Enriquez R,

[12] Lee NJ,

[13] Lin EJ,

[14] Klugmann M,

[15] During M,

[16] Eisman JA,

[17] Li M

[18] et al.

[19] ↵

Baldock PA,

Sainsbury A,

Couzens M,

Enriquez RF,

Thomas GP,

Gardiner EM &

Herzog H

2002 Hypothalamic Y2 receptors regulate bone formation. Journal of Clinical Investigation 109 915–921.doi:10.1172/JCI14588.

[20] Baldock PA,

[21] Sainsbury A,

[22] Couzens M,

[23] Enriquez RF,

[24] Thomas GP,

[25] Gardiner EM &

[26] Herzog H

[27] ↵

Baldock PA,

Sainsbury A,

Allison S,

Lin EJ,

Couzens M,

Boey D,

Enriquez R,

During M,

Herzog H &

Gardiner EM

2005 Hypothalamic control of bone formation: distinct actions of leptin and Y2 receptor pathways. Journal of Bone and Mineral Research 20 1851–1857.doi:10.1359/JBMR.050523.

[28] Baldock PA,

[29] Sainsbury A,

[30] Allison S,

[31] Lin EJ,

[32] Couzens M,

[33] Boey D,

[34] Enriquez R,

[35] During M,

[36] Herzog H &

[37] Gardiner EM

[38] ↵

Baldock PA,

Allison S,

McDonald MM,

Sainsbury A,

Enriquez RF,

Little DG,

Eisman JA,

Gardiner EM &

Herzog H

2006 Hypothalamic regulation of cortical bone mass: opposing activity of Y2 receptor and leptin pathways. Journal of Bone and Mineral Research 21 1600–1607.doi:10.1359/jbmr.060705.

[39] Baldock PA,

[40] Allison S,

[41] McDonald MM,

[42] Sainsbury A,

[43] Enriquez RF,

[44] Little DG,

[45] Eisman JA,

[46] Gardiner EM &

[47] Herzog H

[48] ↵

Baldock PA,

Allison SJ,

Lundberg P,

Lee NJ,

Slack K,

Lin EJ,

Enriquez RF,

McDonald MM,

Zhang L,

During MJ

et al.

2007 Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis. Journal of Biological Chemistry 282 19092–19102.doi:10.1074/jbc.M700644200.

[49] Baldock PA,

[50] Allison SJ,

[51] Lundberg P,

[52] Lee NJ,

[53] Slack K,

[54] Lin EJ,

[55] Enriquez RF,

[56] McDonald MM,

[57] Zhang L,

[58] During MJ

[59] et al.

[60] ↵

Baldock PA,

Lee NJ,

Driessler F,

Lin S,

Allison S,

Stehrer B,

Lin EJ,

Zhang L,

Enriquez RF,

Wong IP

et al.

2009 Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight. PLoS ONE 4 e8415doi:10.1371/journal.pone.0008415.

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[62] Lee NJ,

[63] Driessler F,

[64] Lin S,

[65] Allison S,

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[68] Zhang L,

[69] Enriquez RF,

[70] Wong IP

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Coppari R,

McMinn J,

Liu SM,

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Elefteriou F,

Takeda S,

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[133] Elefteriou F,

[134] Takeda S,

[135] Liu X,

[136] Armstrong D &

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Elefteriou F,

Takeda S,

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Magre J,

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Kim CA,

Ogawa Y,

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Ware SM,

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[140] Takeda S,

[141] Ebihara K,

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Hamrick MW,

Della-Fera MA,

Choi YH,

Pennington C,

Hartzell D &

Baile CA

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[164] Della-Fera MA,

[165] Choi YH,

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[167] Hartzell D &

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Barth F,

Bonner TI,

Cabral G,

Casellas P,

Devane WA,

Felder CC,

Herkenham M,

Mackie K,

Martin BR

et al.

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[170] Howlett AC,

[171] Barth F,

[172] Bonner TI,

[173] Cabral G,

[174] Casellas P,

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[179] Martin BR

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Idris AI,

van 't Hof RJ,

Greig IR,

Ridge SA,

Baker D,

Ross RA &

Ralston SH

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[183] van 't Hof RJ,

[184] Greig IR,

[185] Ridge SA,

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[187] Ross RA &

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Jiang X,

Paic F,

Ma L,

Adams DJ,

Baldock PA,

Pilbeam CC &

Kalajzic I

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[191] Jiang X,

[192] Paic F,

[193] Ma L,

[194] Adams DJ,

[195] Baldock PA,

[196] Pilbeam CC &

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Ishac EJ,

Jiang L,

Lake KD,

Varga K,

Abood ME &

Kunos G

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[199] Ishac EJ,

[200] Jiang L,

[201] Lake KD,

[202] Varga K,

[203] Abood ME &

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[205] ↵

Iwaniec UT,

Boghossian S,

Lapke PD,

Turner RT &

Kalra SP

2007 Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice. Peptides 28 1012–1019.doi:10.1016/j.peptides.2007.02.001.

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[209] Turner RT &

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Karsak M,

Cohen-Solal M,

Freudenberg J,

Ostertag A,

Morieux C,

Kornak U,

Essig J,

Erxlebe E,

Bab I,

Kubisch C

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