Figure 3
Model of genomic shuffling by breakage fusion bridge (BFB) cycles. Dysfunctional telomeres (absent red circles) fuse and form dicentric chromosomes. During cell division, the fused chromosomes are pulled to the two different poles of the emerging daughter cells. During anaphase these can be observed as anaphase bridges, chromosomal material spanning from one daughter cell to the other. Eventually, a break occurs and creates another open end, which can serve as a new starting point for a subsequent BFB. Ultimately, this process leads to genomic amplifications and deletions.
