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This Article Accepted manuscript (PDF) All Versions of this Article: JME-09-0168v1 44/4/195    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Gardner, S. Articles by Pawson, A. PubMed PubMed Citation Articles by Gardner, S. Articles by Pawson, A.

S Gardner, Human Reproductive Sciences Unit, Medical Research Council, Edinburgh, United Kingdom
E Stavrou, Human Reproductive Sciences Unit, Medical Research Council, Edinburgh, United Kingdom
P Rischitor, Human Reproductive Sciences Unit, Medical Research Council, Edinburgh, United Kingdom
E Faccenda, Human Reproductive Sciences Unit, Medical Research Council, Edinburgh, United Kingdom
A Pawson, Human Reproductive Sciences Unit, Medical Research Council, Edinburgh, EH16 4TJ, United Kingdom

Correspondence: Adam Pawson, Email: a.pawson{at}hrsu.mrc.ac.uk

Abstract

The binding of GnRH to its receptor on pituitary gonadotropes leads to the targeting of a diverse array of signalling mediators. These mediators drive multiple signal transduction pathways, which in turn regulate a variety of cellular processes, including the biosynthesis and secretion of the gonadotropins, LH and FSH. Advances in our understanding of the mechanisms and signalling pathways that are recruited to regulate gonadotrope function are continually being made. This review will focus on the recent demonstration that key mediators of the canonical Wnt signalling pathway are targeted by GnRH in gonadotropes, and that these may play essential roles in regulating the expression of many of the key players in gonadotrope biology, including the GnRH receptor and the gonadotropins.