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G Banhegyi, Pathophysiology Experimental Medicine and public Health, University of Siena, Siena, Italy
M Csala, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
A Benedetti, Pathophysiology Experimental Medicine and public Health, University of Siena, Siena, 53100, Italy

Correspondence: Angelo Benedetti, Email: benedetti{at}unisi.it

Abstract

Hexose-6-phosphate dehydrogenase got into the focus of interest due to its role in the prereceptorial activation of glucocorticoids, which has been implicated in the pathomechanism of metabolic syndrome. Genetic observations, results gained in hexose-6-phosphate dehydrogenase knock-out mice and studies on differentiating adipocytes demonstrated the importance of the enzyme in metabolic regulation. A nutrient sensing function can be postulated for the enzyme, which links metabolism to endocrinology in the endoplasmic reticulum. This review provides an overview of recent developments concerning the enzyme and its impact on various branches of the intermediary metabolism that makes it an important subject for the research on obesity, diabetes and metabolic syndrome.

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