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Accepted Preprint first posted online on 11 February 2009

Journal of Molecular Endocrinology 2009;43:1.

Journal of Molecular Endocrinology (2009) In press  DOI: 10.1677/JME-08-0132
© 2009 Society for Endocrinology
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Review

Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders

 Elin Swedenborg, Joelle Ruegg, Sari Makela and Ingemar Pongratz

E Swedenborg, Dept. of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden
J Ruegg, Dept of Biosciences and Nutrition, Karolinska Institute, Huddinge, 14157, Sweden
S Makela, Functional Foods Forum, University of Turku, Turku, Finland
I Pongratz, Dept. of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden

Correspondence: Joelle Ruegg, Email: joerue{at}ki.se

Abstract

Endocrine disruption refers to the ability of chemicals to interfere with hormonal systems, and has raised considerable concern in recent years. Endocrine disruptive chemicals (EDCs) pose a documented risk to wild life and have the potential to negatively influence human health.

This review focuses on the molecular mechanisms of endocrine disruption and the possible involvement of EDCs in metabolic disorders. The first part describes the role of aryl hydrocarbon receptor (AhR) and nuclear receptors (NRs) in mediating effects of EDCs, in particular how cross-talk between AhR and NR pathways can lead to endocrine disruption. The second part deals with how these receptors are involved in metabolic functions and how their targeting by EDCs can lead to disturbances in glucose and fat metabolism. The article illustrates that, although there is accumulating data on molecular mechanisms of EDC action as well as on EDC involvement in metabolic disorders, there is still a great demand for data that can unite the mechanistic and the toxicological/epidemiological observations.






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