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This Article Accepted manuscript (PDF) All Versions of this Article: JME-08-0122v1 42/1/11    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kerkhofs, S. Articles by Claessens, F. Search for Related Content PubMed PubMed Citation Articles by Kerkhofs, S. Articles by Claessens, F.

S Kerkhofs, Molecular Cell Biology, KU Leuven, Leuven, Belgium
S Denayer, Molecular Cell Biology, KU Leuven, Leuven, 3000, Belgium
A Haelens, Molecular Cell Biology, KU Leuven, Leuven, Belgium
F Claessens, Molecular Cell Biology, KU Leuven, Leuven, 3000, Belgium

Correspondence: Frank Claessens, Email: frank.claessens{at}med.kuleuven.be

Abstract

Androgens play an important role in male reproductive development and function. These steroid hormones mediate their actions by binding to the androgen receptor (AR). Diseases like androgen insensitivity syndrome, prostate cancer, Kennedy’s disease and infertility can be caused by mutations in the AR. To get a better insight in the molecular working mechanisms of the AR, several knockout and knock-in mouse models are developed. These models are reviewed here and are compared with human diseases.

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