• Made available online as an Accepted Preprint 3 March 2010
  • Accepted Preprint first posted online on 3 March 2010

Adrenocortical development and cancer: focus on SF-1

  1. Enzo Lalli1,2
  1. 1Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    2Université de Nice, Sophia Antipolis, 06560 Valbonne, France
  1. (Correspondence should be addressed to E Lalli at Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 6097; Email: ninino{at}ipmc.cnrs.fr)

Abstract

Steroidogenic factor-1 (SF-1/Ad4-binding protein; NR5A1) is an essential regulator of tissue-specific gene expression in steroidogenic cells and of adrenogonadal development. Here, I discuss recent data in the literature showing the implication of SF-1 and the importance of its dosage not only during development but also for adrenal cortex tumorigenesis in humans and mice.

  • Revision received 5 February 2010
  • Accepted 2 March 2010
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  1. doi: 10.1677/JME-09-0143 J Mol Endocrinol 44 301-307
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