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Research:
- Luca Morandi,
- Alberto Righi,
- Francesca Maletta,
- Paola Rucci,
- Fabio Pagni,
- Marco Gallo,
- Sabrina Rossi,
- Leonardo Caporali,
- Anna Sapino,
- Ricardo V Lloyd,
- and Sofia Asioli
Somatic mutation profiling of hobnail variant of papillary thyroid carcinoma Endocr Relat Cancer 24 (2) 107-117, doi:10.1530/ERC-16-0546 first published on 6 January 2017
...and Treatment (IRCCS), Candiolo, Italy 10University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA Abstract Hobnail variant of papillary thyroid carcinoma (HPTC) represents a recently described, aggressive and rare group of thyroid tumors with poorly understood pathogenesis...
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Research:
- Soomin Ahn,
- Tae Hyuk Kim,
- Sun Wook Kim,
- Chang Seok Ki,
- Hye Won Jang,
- Jee Soo Kim,
- Jung Han Kim,
- Jun-Ho Choe,
- Jung Hee Shin,
- Soo Yeon Hahn,
- Young Lyun Oh,
- and Jae Hoon Chung
Comprehensive screening for PD-L1 expression in thyroid cancer Endocr Relat Cancer 24 (2) 97-106, doi:10.1530/ERC-16-0421
...Kim contributed equally to this work) Abstract PD-L1 expression is being considered a potential biomarker for response of anti-PD-1 or anti-PD-L1 agents in various tumors. The reported frequency of PD-L1 positivity varies in thyroid carcinomas, and multiple factors may contribute to the variability...
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Research:
- Eric Y Lian,
- Sarah M Maritan,
- Jessica G Cockburn,
- Katayoon Kasaian,
- Mathieu J F Crupi,
- David Hurlbut,
- Steven J M Jones,
- Sam M Wiseman,
- and Lois M Mulligan
Differential roles of RET isoforms in medullary and papillary thyroid carcinomas Endocr Relat Cancer 24 (1) 53-69, doi:10.1530/ERC-16-0393 first published on 21 November 2016
...and constitutively activated in familial and sporadic thyroid carcinomas. As a result of alternative splicing, RET is expressed as two protein isoforms, RET9 and RET51, which differ in their unique C-terminal amino acids. These isoforms have distinct intracellular trafficking and associated signalling complexes...
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Research:
- Xiaopei Shen,
- Rengyun Liu,
- and Mingzhao Xing
A six-genotype genetic prognostic model for papillary thyroid cancer Endocr Relat Cancer 24 (1) 41-52, doi:10.1530/ERC-16-0402 first published on 14 November 2016
...165–177. (doi:10.1007/s12672-016-0256-3) Bullock M, Ren Y, O’Neill C, Gill A, Aniss A, Sywak M, Sidhu S, Delbridge L, Learoyd D, de Vathaire F, et al. 2016 TERT promoter mutations are a major indicator of recurrence and death due to papillary thyroid carcinomas. Clinical Endocrinology 85 283–290. (doi...
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Review:
- Giovanni Vitale,
- Germano Gaudenzi,
- Luisa Circelli,
- Marco F Manzoni,
- Andrea Bassi,
- Niccolò Fioritti,
- Antongiulio Faggiano,
- Annamaria Colao,
- and on behalf of NIKE Group
Animal models of medullary thyroid cancer: state of the art and view to the future Endocr Relat Cancer 24 (1) R1-R12, doi:10.1530/ERC-16-0399 first published on 31 October 2016
...DOI: 10.1530/ERC-16-0399 http://.endocrinology-journals.org © 2017 Society for Endocrinology Printed in Great Britain Published by Bioscientifica Ltd. Abstract Medullary thyroid carcinoma is a neuroendocrine tumour originating from parafollicular C cells accounting for 5–10% of thyroid cancers...
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Research Letter:
- Massimo Bongiovanni,
- Caterina Rebecchini,
- Chiara Saglietti,
- Jean-Luc Bulliard,
- Laura Marino,
- Laurence de Leval,
- and Gerasimos P Sykiotis
Very low expression of PD-L1 in medullary thyroid carcinoma Endocr Relat Cancer 24 (6) L35-L38, doi:10.1530/ERC-17-0104 first published on 18 April 2017
...cells and tumor-infiltrating immune cells, showing that malignant cells are PD-L1-positive in a variable proportion of HL, melanoma, glioblastoma, NSCLC and head and neck, breast, ovarian, renal, pancreatic and esophageal carcinoma (Chowdhury et al. 2016). Regarding thyroid tumors, a few papers have...
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Research:
- Theo S Plantinga,
- Mirela S Petrulea,
- Marije Oosting,
- Leo A B Joosten,
- Doina Piciu,
- Johannes W Smit,
- Romana T Netea-Maier,
- and Carmen E Georgescu
Association of NF-κB polymorphisms with clinical outcome of non-medullary thyroid carcinoma Endocr Relat Cancer 24 (7) 307-318, doi:10.1530/ERC-17-0033 first published on 20 April 2017
...-medullary thyroid carcinoma (NMTC) populations. No. (%) Variable Romanian NMTC cohort Dutch NMTC cohort P value Patients 157 138 Age (years) 55 (14–76) 39 (8–65) 0.76 Gender (F/M) 137/20 (87.3/12.7) 104/34 (75.4/24.6) 0.008 Tumor histology PTC 111 (70.7) 99 (71.7) 0.47 FTC 37 (23.6) 34 (24.6) FVPTC 9 (5.7) 4 (2...
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Review:
- Alfred King-yin Lam and
- Nassim Saremi
Cribriform-morular variant of papillary thyroid carcinoma: a distinctive type of thyroid cancer Endocr Relat Cancer 24 (4) R109-R121, doi:10.1530/ERC-17-0014
...DOI: 10.1530/ERC-17-0014 http://.endocrinology-journals.org © 2017 Society for Endocrinology Printed in Great Britain Published by Bioscientifica Ltd. 24:4 Review A K-y Lam and N Saremi Cribriform papillary thyroid carcinoma 10.1530/ERC-17-0014 Alfred King-yin Lam and Nassim Saremi Cancer Molecular...
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Research:
- Trynke van der Boom,
- Esther N Klein Hesselink,
- Hilde A M Kooistra,
- Karina Meijer,
- Anouk N A van der Horst-Schrivers,
- Joop D Lefrandt,
- and Thera P Links
Risk factors for venous thromboembolism in patients treated for differentiated thyroid carcinoma Endocr Relat Cancer 24 (6) 267-273, doi:10.1530/ERC-17-0013
...for venous thromboembolic events in patients with differentiated thyroid carcinoma (DTC) have never been assessed. This is remarkable, as several parts of the treatment comprise a hypoagulable state that could in subgroups of DTC patients lead to an increased risk of VTE. The aim of this study was to assess...
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Research:
- Kirk Jensen,
- Athanasios Bikas,
- Aneeta Patel,
- Yevgeniya Kushchayeva,
- John Costello,
- Dennis McDaniel,
- Kenneth Burman,
- and Vasyl Vasko
Nelfinavir inhibits proliferation and induces DNA damage in thyroid cancer cells Endocr Relat Cancer 24 (3) 147-156, doi:10.1530/ERC-16-0568 first published on 30 January 2017
...to become a new thyroid cancer therapeutic agent. Keywords thyroid carcinoma Introduction Thyroid cancer is the most common endocrine malignancy ( Hundahl et al . 1998 ) and is also increasing at the fastest incidence rate of any malignancy ( Morris et al . 2016 ). Patients with differentiated thyroid...

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