Searching journal content for androgen deprivation therapy (as phrase) in full text.

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  1. Review:
    • Gido Snaterse,
    • Jenny A Visser,
    • Wiebke Arlt,
    • and Johannes Hofland
    Circulating steroid hormone variations throughout different stages of prostate cancer Endocr Relat Cancer 24 (11) R403-R420, doi:10.1530/ERC-17-0155 first published on 18 September 2017
    ...androgen deprivation therapy and/or abiraterone with prednisone. Thus, we will primarily discuss those stages and treatment modalities. This overview summarizes our understanding of steroid fluxes and how they may relate to prostate cancer progression. As the AR continues to constitute a key driving ~~~
  2. Review:
    • Gianmarco Leone,
    • Marcello Tucci,
    • Consuelo Buttigliero,
    • Clizia Zichi,
    • Daniele Pignataro,
    • Paolo Bironzo,
    • Francesca Vignani,
    • Giorgio Scagliotti,
    • and Massimo Di Maio
    Anti-androgen withdrawal syndrome (AAWS) in the treatment of patients with prostate cancer Endocr Relat Cancer ERC-17-0355, doi:10.1530/ERC-17-0355 first published on 28 September 2017
    ...androgen deprivation therapy (ADT). The crucial role of 37 androgen receptor (AR) in disease development and progression (Parker et al. 2015) makes PCa 38 extremely sensitive to surgical or biochemical castration. Moreover, recent findings showed that in 39 patients with high-risk and/or high-volume ~~~
  3. Review:
    • Melissa Gamat and
    • Douglas G McNeel
    Androgen deprivation and immunotherapy for the treatment of prostate cancer Endocr Relat Cancer ERC-17-0145, doi:10.1530/ERC-17-0145 first published on 16 August 2017
    ...androgen deprivation therapy can include approaches that decrease serum 94 androgen levels by orchiectomy or by targeting gonadotrophin releasing hormone (e.g. leuprolide, 95 goserelin, degarelix), with or without blockade of the androgen receptor with nonsteroidal anti-96 androgens (e.g. bicalutami ~~~
  4. Review:
    • Takuma Uo,
    • Stephen R Plymate,
    • and Cynthia C Sprenger
    Allosteric alterations in the androgen receptor and activity in prostate cancer Endocr Relat Cancer 24 (9) R335-R348, doi:10.1530/ERC-17-0108
    ...androgen deprivation therapy (ADT) has been the first-line treatment for metastatic prostate cancer (mPCa) (Huggins & Hodges 1941, Sharifi  et  al. 2010, Sharifi 2015a,b). Mechanistically, ADT targets androgen dependence of the androgen receptor (AR) by lowering the availability of the androgen liga ~~~
  5. Thematic Review:
    • Roberta Visconti and
    • Domenico Grieco
    Fighting tubulin-targeting anticancer drug toxicity and resistance Endocr Relat Cancer 24 (9) T107-T117, doi:10.1530/ERC-17-0120
    ...androgen deprivation therapy related to androgen receptor (AR) are depicted. Other mechanisms of resistance have been described, such as androgen-independent activation of AR mediated by oncogenic signaling (see text and Wadosky & Koochekpour 2016). (A) Castration-resistant prostate cells overexpres ~~~
  6. Review:
    • Nicholas Russell,
    • Ada Cheung,
    • and Mathis Grossmann
    Estradiol for the mitigation of adverse effects of androgen deprivation therapy Endocr Relat Cancer 24 (8) R297-R313, doi:10.1530/ERC-17-0153 first published on 30 June 2017
    ...androgen deprivation therapy 10.1530/ERC-17-0153 Nicholas Russell1,2, Ada Cheung1,2 and Mathis Grossmann1,2 1Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia 2Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, Victoria, Australia Abstract Pros ~~~
  7. Review:
    • Sangeeta Kumari,
    • Dhirodatta Senapati,
    • and Hannelore V Heemers
    Rationale for the development of alternative forms of androgen deprivation therapy Endocr Relat Cancer 24 (8) R275-R295, doi:10.1530/ERC-17-0121 first published on 31 May 2017
    ...androgen deprivation therapy (ADT) (Nguyen  et al. 2014, Magnan  et al. 2015, Valenca  et  al. 2015, Attard  et  al. 2016), failure of ADT is still a clinical reality that contributes directly to the ~30,000 CaP deaths in the US annually (Siegel  et  al. 2017). Aberrant re-activation of AR has been ~~~
  8. Research:
    • Tianzhu Zang,
    • Mary-Ellen Taplin,
    • Daniel Tamae,
    • Wanling Xie,
    • Clementina Mesaros,
    • Zhenwei Zhang,
    • Glenn Bubley,
    • Bruce Montgomery,
    • Steven P Balk,
    • Elahe A Mostaghel,
    • Ian A Blair,
    • and Trevor M Penning
    Testicular vs adrenal sources of hydroxy-androgens in prostate cancer Endocr Relat Cancer 24 (8) 393-404, doi:10.1530/ERC-17-0107 first published on 29 June 2017
    ...androgen deprivation therapy (NADT) is one strategy for the treatment of early-stage prostate cancer; however, the long-term outcomes of NADT with radical prostatectomy including biochemical failure-free survival are not promising. One proposed mechanism is incomplete androgen ablation. In this stud ~~~
  9. Review:
    • Bethany Smith,
    • Priyanka Agarwal,
    • and Neil A Bhowmick
    MicroRNA applications for prostate, ovarian and breast cancer in the era of precision medicine Endocr Relat Cancer 24 (5) R157-R172, doi:10.1530/ERC-16-0525 first published on 13 March 2017
    ...androgen deprivation therapy NCT01503229 Interventional University of Washington Abiraterone acetate in treating patients with metastatic hormone-resistant prostate cancer NCT01220427 Observational Wuerzburg University Hospital microRNA expression profiles in high risk prostate cancer NCT02471469 Ob ~~~
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  10. Review:
    • Niamh L Mundell,
    • Robin M Daly,
    • Helen Macpherson,
    • and Steve F Fraser
    Cognitive decline in prostate cancer patients undergoing ADT: a potential role for exercise training Endocr Relat Cancer 24 (4) R145-R155, doi:10.1530/ERC-16-0493 first published on 16 February 2017
    ...androgen deprivation therapy R146Review N L Mundell et al. A potential role for exise training DOI: 10.1530/ERC-16-0493 http://.endocrinology-journals.org © 2017 Society for Endocrinology Printed in Great Britain Published by Bioscientifica Ltd. 24:4 musculoskeletal health, an increase in cardiometa ~~~
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