Endocrine-Related Cancer

G protein-coupled receptor expression in the adult and fetal adrenal glands

Yewei Xing, Yasuhiro Nakamura, and William E. Rainey

Molecular and Cellular Endocrinology (2009) 300 :43

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GnRH and GnRH receptors in the pathophysiology of the human female reproductive system

Roberto Maggi, Anna Maria Cariboni, Marina Montagnani Marelli, Roberta Manuela Moretti, Valentina Andrè, Monica Marzagalli, and Patrizia Limonta

Human Reproduction Update (2016) 22 :358

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Four functional GnRH receptors in zebrafish: analysis of structure, signaling, synteny and phylogeny

J. A. Tello, S. Wu, J. E. Rivier, and N. M. Sherwood

Integrative and Comparative Biology (2008) 48 :570

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Effects of the gonadotropin-releasing hormone antagonist cetrorelix in the early postimplantation period on rat pregnancy

Niyazi Tug, Unal Uslu, Alev Cumbul, Signem Eyuboglu, Cetin Cam, Ates Karateke, and Bayram Yilmaz

European Journal of Obstetrics & Gynecology and Reproductive Biology (2011) 155 :166

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Is the metalloendopeptidase EC 3.4.24.15 (EP24.15), the enzyme that cleaves luteinizing hormone-releasing hormone (LHRH), an activating enzyme?

K. Cleverly and T J. Wu

Reproduction (2010) 139 :319

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Gemcitabine Based Peptide Conjugate with Improved Metabolic Properties and Dual Mode of Efficacy

Theodoros Karampelas, Eleni Skavatsou, Orestis Argyros, Demosthenes Fokas, and Constantin Tamvakopoulos

Molecular Pharmaceutics (2017) 14 :674

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Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats

Dag Erlend Olberg, Sven H. Hausner, Nadine Bauer, Jo Klaveness, Bård Indrevoll, Kjetil Wessel Andressen, Marie Dahl, Finn Olav Levy, Julie L. Sutcliffe, and Ira Haraldsen

Med. Chem. Commun. (2015) 6 :708

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Gonadotrophin-releasing hormone (GnRH)

S P H Alexander, A Mathie, and J A Peters

British Journal of Pharmacology (2006) :S46

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GNRH1mutations in patients with idiopathic hypogonadotropic hypogonadism

Yee-Ming Chan, Adelaide de Guillebon, Mariarosaria Lang-Muritano, Lacey Plummer, Felecia Cerrato, Sarah Tsiaras, Ariana Gaspert, Hélène B. Lavoie, Ching-Hui Wu, William F. Crowley, John K. Amory, Nelly Pitteloud, and Stephanie B. Seminara

Proceedings of the National Academy of Sciences (2009) 106 :11703

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Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression

Dag Erlend Olberg, Kjetil Wessel Andressen, Finn Olav Levy, Jo Klaveness, Ira Haraldsen, and Julie L. Sutcliffe

Bioorganic & Medicinal Chemistry Letters (2014) 24 :1846

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GnRH-Gemcitabine Conjugates for the Treatment of Androgen-Independent Prostate Cancer: Pharmacokinetic Enhancements Combined with Targeted Drug Delivery

Theodoros Karampelas, Orestis Argyros, Nisar Sayyad, Katerina Spyridaki, Charalampos Pappas, Kevin Morgan, George Kolios, Robert P Millar, George Liapakis, Andreas G. Tzakos, Demosthenes Fokas, and Constantin Tamvakopoulos

Bioconjugate Chemistry (2014) 25 :813

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Insights into thymic aging and regeneration

Dennis D. Taub and Dan L. Longo

Immunological Reviews (2005) 205 :72

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LHRH-PE40 Fusion Protein Tethered Silica Nanorattles for Imaging-Guided Tumor-Specific Drug Delivery and Bimodal Therapy

Fuping Gao, Linlin Li, Changhui Fu, Liya Nie, Dong Chen, and Fangqiong Tang

Advanced Materials (2013) 25 :5508

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Different Signal Responses to Lamprey GnRH-III in Human Cancer Cells

Krisztina Herédi-Szabó, Richard F. Murphy, and Sándor Lovas

International Journal of Peptide Research and Therapeutics (2006) 12 :359

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Gonadotropin-releasing hormone (GnRH)

British Journal of Pharmacology (2009) 158 :S57

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Effects of inhibition of gonadotropin releasing hormone secretion on the response to novel objects in young male and female sheep

Jane E. Robinson, Neil P. Evans, Rebecca Dumbell, Anne-Kristin Solbakk, Erik Ropstad, and Ira Ronit Hebold Haraldsen

Psychoneuroendocrinology (2014) 40 :130

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GnRH-(1–5) activates matrix metallopeptidase-9 to release epidermal growth factor and promote cellular invasion

Madelaine Cho-Clark, Darwin O. Larco, Brian R. Zahn, Shaila K. Mani, and T. John Wu

Molecular and Cellular Endocrinology (2015) 415 :114

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Localization of gonadotrophin-releasing hormone I, bradykinin and their receptors in the ovaries of non-mammalian vertebrates

P. Singh, A. Krishna, and R. Sridaran

Reproduction (2007) 133 :969

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GnRH participates in the self-renewal of A549-derived lung cancer stem-like cells through upregulation of the JNK signaling pathway

Chi Lu, Ting Huang, Weiqun Chen, and Hongda Lu

Oncology Reports (2015) :

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Reporter transgenic mouse models highlight the dual endocrine and neural facet of GnRH receptor function

Anne-Laure Schang, Raymond Counis, Solange Magre, Christian Bleux, Anne Granger, Valérie Ngô-Muller, Marie-Claude Chenut, Muhammad Ishaq, Joelle Cohen-Tannoudji, and Jean-Noël Laverrière

Annals of the New York Academy of Sciences (2011) 1220 :16

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Chorionic Gonadotropin and Its Receptor Are Both Expressed in Human Retina, Possible Implications in Normal and Pathological Conditions

Sladjana Dukic-Stefanovic, Jan Walther, Sebastian Wosch, Gerolf Zimmermann, Peter Wiedemann, Henry Alexander, Thomas Claudepierre, and Alvaro Rendon

PLoS ONE (2012) 7 :e52567

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7TM RECEPTORS

British Journal of Pharmacology (2009) 158 :S5

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GnRH-analogues and oral contraceptives for fertility preservation in women during chemotherapy

Z. Blumenfeld and M. von Wolff

Human Reproduction Update (2008) 14 :543

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Regulation of local steroidogenesis in the brain and in prostate cancer: Lessons learned from interdisciplinary collaboration

H. Bobby Fokidis, Hans H. Adomat, Geetanjali Kharmate, Elham Hosseini-Beheshti, Emma S. Guns, and Kiran K. Soma

Frontiers in Neuroendocrinology (2015) 36 :108

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Effects of the Gonadotropin-Releasing Hormone Antagonist Ganirelix on Normal Micturition and Prostaglandin E2–Induced Detrusor Overactivity in Conscious Female Rats

Andrea Russo, Fabio Castiglione, Andrea Salonia, Fabio Benigni, Patrizio Rigatti, Francesco Montorsi, Karl-Erik Andersson, and Petter Hedlund

European Urology (2011) 59 :868

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A review of the current status of siRNA nanomedicines in the treatment of cancer

Pauline Resnier, Tristan Montier, Véronique Mathieu, Jean-Pierre Benoit, and Catherine Passirani

Biomaterials (2013) 34 :6429

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Gonadotropin-releasing hormone receptors as molecular therapeutic targets in prostate cancer: Current options and emerging strategies

Patrizia Limonta and Marilena Manea

Cancer Treatment Reviews (2013) 39 :647

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Abrin Immunotoxin: Targeted Cytotoxicity and Intracellular Trafficking Pathway

Sudarshan Gadadhar, Anjali A. Karande, and Arun Rishi

PLoS ONE (2013) 8 :e58304

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Brain penetrant small molecule 18F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats

Dag E. Olberg, Nadine Bauer, Kjetil W. Andressen, Trine Hjørnevik, Paul Cumming, Finn O. Levy, Jo Klaveness, Ira Haraldsen, and Julie L. Sutcliffe

Nuclear Medicine and Biology (2016) 43 :478

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The hypothalamic–pituitary–gonadal axis and prostate cancer: implications for androgen deprivation therapy

Luis A. Kluth, Shahrokh F. Shariat, Christian Kratzik, Scott Tagawa, Guru Sonpavde, Malte Rieken, Douglas S. Scherr, and Karl Pummer

World Journal of Urology (2014) 32 :669

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Membrane rafts and GnRH receptor signaling

Amy M. Navratil, Stuart P. Bliss, and Mark S. Roberson

Brain Research (2010) 1364 :53

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Gonadotropin‑releasing hormone inhibits the proliferation and motility of nasopharyngeal carcinoma cells

Loong Teng, Munirah Ahmad, Wayne Ng, Subathra Sabaratnam, Maria Rasan, Ishwar Parhar, and Alan Khoo

Molecular Medicine Reports (2015) :

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Dry heat forced degradation of buserelin peptide: Kinetics and degradant profiling

Matthias D’Hondt, Maria Fedorova, Chien-Yu Peng, Bert Gevaert, Lien Taevernier, Ralf Hoffmann, and Bart De Spiegeleer

International Journal of Pharmaceutics (2014) 467 :48

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Implications of apoptosis in cancer immunotherapy

Gregory Lee and Bixia Ge

Advances in Bioscience and Biotechnology (2012) 03 :679

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Gallium-68: Chemistry and Radiolabeled Peptides Exploring Different Oncogenic Pathways

Clément Morgat, Elif Hindié, Anil K. Mishra, Michèle Allard, and Philippe Fernandez

Cancer Biotherapy & Radiopharmaceuticals (2013) 28 :85

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Luteinizing hormone-releasing hormone (LHRH) receptor agonists vs antagonists: a matter of the receptors?

Yuri Tolkach, Steven Joniau, and Hendrik Van Poppel

BJU International (2013) 111 :1021

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Discovery of the genes in putative GnRH signaling pathway with focus on characterization of GnRH-like receptor transcripts in the brain and ovary of the oriental river prawn Macrobrachium nipponense

Yu-Xin Du, Ke-Yi Ma, and Gao-Feng Qiu

Aquaculture (2015) 442 :1

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Paclitaxel conjugation with the analog of the gonadotropin-releasing hormone as a targeting moiety

Marie Pribylova, Marcela Dvorakova, Veronika Hanusova, Ingrid Nemethova, Lenka Skalova, and Tomas Vanek

International Journal of Pharmaceutics (2011) 415 :175

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Gonadotropin-releasing Hormone Receptor Expression in Endometrial Cancer

Yong-Tark Jeon, Yong-Beom Kim, So Yeon Park, Jae Weon Kim, Noh-Hyun Park, Soon-Beom Kang, and Yong-Sang Song

International Journal of Gynecological Pathology (2009) 28 :19

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Luliberin analogues exhibiting a cytotoxic effect on tumor cells in vitro

S. V. Burov, T. V. Yablokova, M. Yu. Dorosh, Z. P. Shkarubskaya, M. Blank, N. Epstein, and M. Fridkin

Russian Journal of Bioorganic Chemistry (2006) 32 :413

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Effect of gonadotropin-releasing hormone agonist on ES-2 ovarian cancer cells

Kuan-Hao Tsui, Wen-Ling Lee, Kok-Min Seow, Lin-Wei Yang, Shih-Yi Wang, Peng-Hui Wang, Chi-Lun Chang, Ming-Shyen Yen, Jiin-Tsuey Cheng, and Chih-Ping Chen

Taiwanese Journal of Obstetrics and Gynecology (2014) 53 :35

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The role of gonadotropin releasing hormone in normal and pathologic endocrine processes

Micol S Rothman and Margaret E Wierman

Current Opinion in Endocrinology, Diabetes and Obesity (2007) 14 :306

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Expression of mRNA and proteins for GnRH I and II and their receptors in primate corpus luteum during menstrual cycle

Nilkanta Chakrabarti, Thenmozhi Subbarao, Anamika Sengupta, Fuhua Xu, Richard L. Stouffer, and Rajagopala Sridaran

Molecular Reproduction and Development (2008) 75 :1567

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Gonadotropin-releasing hormone receptor-targeted paclitaxel-degarelix conjugate: synthesis andin vitroevaluation

Chenhong Wang, Yongtao Ma, Siliang Feng, Keliang Liu, and Ning Zhou

Journal of Peptide Science (2015) 21 :569

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Gonadotropin-releasing hormone-1 (GnRH-1) is involved in tooth maturation and biomineralization

Jean Tiong, Thomas Locastro, and Susan Wray

Developmental Dynamics (2007) 236 :2980

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Presence of immunoreactive gonadotropin releasing hormone (GnRH) and its receptor (GnRHR) in rat ovary during pregnancy

Anamika Sengupta, Nilkanta Chakrabarti, and Rajagopala Sridaran

Molecular Reproduction and Development (2008) 75 :1031

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Receptor-Targeting Phthalocyanine Photosensitizer for Improving Antitumor Photocytotoxicity

Peng Xu, Jincan Chen, Zhuo Chen, Shanyong Zhou, Ping Hu, Xueyuan Chen, Mingdong Huang, and Daniel Monleon

PLoS ONE (2012) 7 :e37051

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Peri-pubertal gonadotropin-releasing hormone agonist treatment affects sex biased gene expression of amygdala in sheep

Syed Nuruddin, Anette Krogenæs, Ola Brønstad Brynildsrud, Steven Verhaegen, Neil P. Evans, Jane E. Robinson, Ira Ronit Hebold Haraldsen, and Erik Ropstad

Psychoneuroendocrinology (2013) 38 :3115

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Pituitary and ovarian responses after an application of a low dose of the luteinizing hormone-releasing hormone (LHRH)-lytic peptide conjugate during the preovulatory period in ewes

Bret A McLeod, William Hansel, Pawel M Bartlewski, and Genje Buenviaje

journal of Cancer Therapeutics and Research (2013) 2 :4

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Leuprolide acetate: a drug of diverse clinical applications

Andrea C Wilson, Sivan Vadakkadath Meethal, Richard L Bowen, and Craig S Atwood

Expert Opinion on Investigational Drugs (2007) 16 :1851

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The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

Stephen P.H. Alexander, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Joanna L. Sharman, Michael Spedding, John A. Peters, and Anthony J. Harmar

British Journal of Pharmacology (2013) 170 :1459

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Zmiany morfologiczne i enzymatyczne wywołane długoterminowym podawaniem samicom szczura niskiej dawki agonisty i antagonisty gonadoliberyny.

Aleksandra Suszka-Świtek, Piotr Czekaj, Jacek Pająk, Rafał Skowronek, Katarzyna Wrona-Bogus, Danuta Plewka, Danuta Kozłowska-Rup, Ryszard Wiaderkiewicz, and Andrzej Jankowski

Medical Science Monitor (2012) 18 :BR315

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Gonadotropin releasing hormone receptor gene and protein expression and immunohistochemical localization in bovine uterus and oviducts

R. Singh, M.L. Graves, C.D. Roskelley, G. Giritharan, and R. Rajamahendran

Domestic Animal Endocrinology (2008) 34 :319

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Gonadotropin-Releasing Hormone Stimulates Biliary Proliferation by Paracrine/Autocrine Mechanisms

Debolina Ray, Yuyan Han, Antonio Franchitto, Sharon DeMorrow, Fanyin Meng, Julie Venter, Matthew McMillin, Lindsey Kennedy, Heather Francis, Paolo Onori, Romina Mancinelli, Eugenio Gaudio, Gianfranco Alpini, and Shannon S. Glaser

The American Journal of Pathology (2015) 185 :1061

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Regulation of Expression of Mammalian Gonadotrophin-Releasing Hormone Receptor Genes

J. P. Hapgood, H. Sadie, W. van Biljon, and K. Ronacher

Journal of Neuroendocrinology (2005) 17 :619

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GPCR-I-TASSER: A Hybrid Approach to G Protein-Coupled Receptor Structure Modeling and the Application to the Human Genome

Jian Zhang, Jianyi Yang, Richard Jang, and Yang Zhang

Structure (2015) 23 :1538

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Diversity of actions of GnRHs mediated by ligand-induced selective signaling

Robert P. Millar, Adam J. Pawson, Kevin Morgan, Emilie F. Rissman, and Zhi-Liang Lu

Frontiers in Neuroendocrinology (2008) 29 :17

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Synthesis, characterization and systematic comparison of FITC-labelled GnRH-I, -II and -III analogues on various tumour cells

József Murányi, Pál Gyulavári, Attila Varga, Györgyi Bökönyi, Henriette Tanai, Tibor Vántus, Domonkos Pap, Krisztina Ludányi, Gábor Mező, and György Kéri

Journal of Peptide Science (2016) 22 :552

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Endocrine-Related Cancer

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