The image depicts pedigrees and germline variants detected in families with a history of SI-NETs. Filled symbols, clinically affected subjects; circles, females; squares, males; diamonds, unknown gender; arrows, all affected and control subjects studied for mutations. Different variants that were considered as candidates for mutations contributing to disease development are depicted in different colors and explained in the legend under each pedigree. All these variants were present as a single allele in the germline of the tested individuals. From Dumanski et al. 24 427–443. Credit: JP Dumanski, C Rasi, ET Janson (Uppsala University, Sweden)