Figure 1
The bioenergetic and biosynthetic requirements of cancer cells are balanced by regulating the flux of pathways that metabolize
glucose, glutamine, or fatty acids. Key regulatory mechanisms that determine the flux from each carbon source into the pathways
are highlighted. The model shows HIF-1α and AMPK driving increased bioenergetic input derived from glucose and fatty acids.
PKM2, TIGAR, or c-Myc can promote the flux of glucose or glutamine into biosynthetic pathways. SCO2 promotes glucose oxidation
via the TCA cycle.