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Figure 1

The bioenergetic and biosynthetic requirements of cancer cells are balanced by regulating the flux of pathways that metabolize glucose, glutamine, or fatty acids. Key regulatory mechanisms that determine the flux from each carbon source into the pathways are highlighted. The model shows HIF-1α and AMPK driving increased bioenergetic input derived from glucose and fatty acids. PKM2, TIGAR, or c-Myc can promote the flux of glucose or glutamine into biosynthetic pathways. SCO2 promotes glucose oxidation via the TCA cycle.

This Article

  1. Endocr Relat Cancer vol. 17 no. 4 R287-R304