Table 2

Multigene parameters in breast cancer

Gene signature Number of genes assessed Tissue Application Trials
MammaPrint 70 Fresh frozen Prognostic for recurrence within 5 years in all node-negative and node-positive patients MINDACT
Oncotype DX 21 FFPE Residual risk of DR in ER-positive patients treated with tamoxifen or AIs; and predictive of chemotherapy benefit in node-negative ER-positive patients TAILORx
Genomic-grade index 97 Originally fresh frozen, validated for FFPE Prognostic, prediction of relapse in endocrine-treated ER-positive breast cancer
Molecular grade index 5 FFPE Predicts poor outcome despite endocrine therapy in ER-positive breast cancer
Rotterdam signature 76 Fresh frozen Prognostic for development of distant metastases within 5 years
  • FFPE, formalin-fixed, paraffin-embedded; ER, estrogen receptor; DR, distant recurrence; AI, aromatase inhibitor.

This Article

  1. Endocr Relat Cancer vol. 17 no. 4 R245-R262