Novartis, Bayer Dana-Farber/Harvard Cancer Center Ph I NCT00942682 |
Sorafenib plus RAD001 |
Advanced low- or intermediate-grade unresectable carcinoid or pancreatic NET |
Safety maximum tolerated dose (MTD) |
Novartis Dana-Farber/Harvard Cancer Center Ph I NCT00804336 |
Pasireotide (somatostatin analogue with affinity for somatostatin receptor 1,2,3,5) plus RAD001 |
Unresectable or metastatic low- or intermediate-grade NET |
Safety MTD |
NCI UCSF Helen Diller Family Comprehensive Cancer Center Ph I/II NCT00227617 |
Fluorouracil, leucovorin and oxaliplatin (FOLFOX) plus bevacizumab |
Advanced NETs, carcinoid, pancreatic islet cell, poorly differentiated NETs of any primary site |
Safety RR |
Dana-Faber Cancer Institute Ph I/II NCT00576680 |
RAD001 plus temozolomide |
Advanced pancreatic NETs |
Safety RR |
Stanford Cancer Center Ph II NCT00398320 |
Capecitabine, oxaliplatin and bevacizumab |
Metastatic/unresectable NETs |
TTP |
Hoffman-LaRoche Ph II NCT00448136 |
Streptozotocin/5FU plus bevacizumab (duodeno-pancreatic) |
Well-differentiated GI or duodeno-pancreatic NETs |
Safety RR |
|
Capecitabine plus bevacizumab (GI) |
|
|
MD Anderson Cancer Center, Texas Ph II NCT00454363 |
Pazopanib |
Low- or intermediate-grade advanced carcinoid or pancreatic islet cell carcinoma |
RR |
Cambridge, UK Randomised Ph II NCT00602082 |
Cap-strep versus Cap-cist |
NETs of foregut, unknown primary, progressing disease |
RR |
Stanley S Scott Cancer Center, New Orleans Ph II NCT00590343 |
PTK787/ZK222584 (vatalanib) |
Metastatic NETs with biochemical evidence of disease |
Biochemical RR and symptom relief |
Toronto Western Hospital Ph I/II NCT00605566 |
Sorafenib plus cyclophosphamide |
Advanced progressive NETs |
Toxicity |
|
|
|
Pharmaco-dynamic end points |
Memorial Sloan-Kettering Cancer Center Ph II NCT00610129 |
MK-0646 humanised monoclonal antibody to IGF1R |
Metastatic well-differentiated NETs |
|
Holden Comprehensive Cancer Center, Iowa Ph II NCT00627198 |
PTK787/ZK222584 (vatalanib) plus Sandostatin LAR |
Progressing NETs with biochemical evidence of disease |
RR and biochemical RR |
ImClone LLC Ph II NCT00781911 |
Cixutumumab (IMC-A12, targeting IGF1R) plus depot octreotide |
Well- or moderately differentiated metastatic NET |
6-month PFS |
UCSF Helen Diller Family Comprehensive Cancer Center Ph II NCT00843531 |
RAD001 plus erlotinib |
Well- to moderately-differentiated NET: low- or intermediate-grade, islet cell carcinoma, pancreatic NET, carcinoid, atypical
carcinoid, paraganglioma, pheochromocytoma
|
Safety RR |
Herbert Irving Comprehensive Cancer Center, Columbia Ph II NCT00869050 |
Temozolomide plus capecitabine |
Progressive metastatic NET |
RR Safety |
Genentech Stanford Cancer Center Ph II NCT00947167 |
Pertuzumab (HER2 inhibiting monoclonal antibody) as monotherapy plus erlotinib |
Unresectable or metastatic well-differentiated NET |
RR |
Novartis Ph III |
Sandostatin LAR +/−RAD001 |
Carcinoids |
PFS |
Novartis Ph II |
5FU+strep+Sandostatin LAR versus 5FU+strep+Pasireotide LAR |
Non-functional pancreatic |
RR, TTP |
Beaufour Ipsen International Ph III NCT00353496 |
Lanreotide versus placebo |
Locally advanced or metastatic well- or moderately differentiated GEP NETs with no hormone-related symptoms |
PFS |