Figure 3
Lineage-specific distribution of histone H3 methylation on lysine 4 guides FoxA1 recruitment. Differentiated cells are characterized
by a unique distribution of epigenetic marks. FoxA1 will specifically be recruited to genomic regions harboring the forkhead
motif (FKH) marked by H3K4me1/me2. Through its chromatin-remodeling activity, neighboring chromatin will be further opened
and accessible to other transcription factors such as ERα and AR in breast and prostate cancer cells respectively. By contrast,
FKH regions lacking H3K4me1/me2 will typically associate with H3K9me2 and be deprived of FoxA1 recruitment. Hence, the lineage-specific
distribution of H3K4me1/me2 and H3K9me2 guides FoxA1 binding, which in turn restricts the recruitment of other transcription
factors.