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Figure 2

Chromatin architecture reprogramming in castration-resistant prostate cancer cells. Similar to ERα in breast cancer cell lines, AR is recruited to a fraction of its putative binding sites in androgen-dependent prostate cancer cells. In castration-resistant prostate cancer cells, the genome-wide AR recruitment pattern is altered. This is dependent on the reprogramming of the chromatin architecture typified by de novo methylation of lysine 4 on histone H3 (H3K4me).

This Article

  1. Endocr Relat Cancer vol. 16 no. 2 381-389