Figure 1
Lineage- and stimuli-specific transcriptional programs are dependent on differential recruitment of ERα. Thousands of putative
ERα-binding sites are found across the human genome. This includes over 60 000 estrogen-responsive elements (EREs) and a number
of regions recruiting ERα through a tethering mechanism. However, lineage-specific ERα recruitment, as reported between breast
and osteosarcoma cancer cell lines, is central to the unique transcriptional program generated in each cell type following
estrogen (E2) treatment. Similarly, the transcriptional program activated through the PI3K/AKT pathway in MCF7 cells expressing a constitutively
active AKT (CA-AKT) is dependent on a unique ERα recruitment pattern.