Criteria used to establish the diagnosis of primary aldosterone-producing adenoma (APA) in the studies reviewed
| Study | ARR | Saline infusion test | Postural test | Preoperative response to spironolactone | CT scan | MRI | Adrenal venous sampling | 131I-6-β-iodocholesterol scintigraphy |
|---|---|---|---|---|---|---|---|---|
| Favia et al. 1992 | + | + | + | − | + | − | + | + |
| Obara et al. 1992 | + | − | + | − | + | − | + | + |
| Simon et al. 1993 | + | + | + | − | + | − | − | − |
| Blumenfeld et al. 1994 | + | − | + | − | + | − | + | − |
| Weigel et al. 1994 | + | − | − | − | + | − | + | − |
| Mantero et al. 1995 | + | − | + | − | + | − | + | + |
| Celen et al. 1996 | + | − | + | + | + | − | + | + |
| Lo et al. 1996 | + | − | + | − | + | − | + | − |
| Proye et al. 1998 | + | − | − | + | + | + | + | + |
| Sirén et al. 1998 | + | − | + | − | + | + | − | + |
| Sapienza et al. 1999 | + | + | + | − | + | + | + | + |
| Shen et al. 1999 | + | − | + | − | + | − | + | + |
| Brunt et al. 2001 | + | − | − | − | + | − | + | − |
| Sawka et al. 2001 | + | − | − | − | + | + | + | − |
| Fukudome et al. 2002 | + | − | − | − | − | − | − | − |
| Rossi et al. 2002 | + | − | − | − | + | − | − | − |
| Harris et al. 2003 | + | − | + | + | + | + | + | + |
| Meria et al. 2003 | + | − | − | − | + | − | + | − |
| Stowasser et al. 2003 | + | − | + | − | + | − | + | − |
| Goh et al. 2004 | + | − | + | − | + | − | + | − |
| Meyer et al. 2005 | + | + | + | − | + | + | − | − |
| Pang et al. 2007 | + | − | − | − | − | − | − | − |
| Gockel et al. 2007 | + | − | − | − | + | + | − | − |
ARR, plasma aldosterone/plasma renin activity ratio; CT, computed tomography, MRI, magnetic resonance imaging.