Medical treatment as an alternative to adrenalectomy in patients with aldosterone-producing adenomas

Table 1

Characteristics of patients and outcome data in the studies reviewed

Study	Number of patients (n)	Cured (%)	BP cut-off (mmHg)	Length of follow-up (months, range or mean±s.d.)	Size of tumours (cm; range)	Incidence of complications (%)
Favia et al. 1992	52	71	DBP<100	77 (13–189)	NM	1.9
Obara et al. 1992	63	62	160/95	49.2 (12–114)	NM	NM
Simon et al. 1993	10	54	160/95	26.4 (6–66)	1.0–3.0	NM
Blumenfeld et al. 1994	43	35	140/90	0.5–180	NM	NM
Weigel et al. 1994	35	59	140/90	36	1.48	NM
Mantero et al. 1995	34	61	NM	NM (12–240)	NM	NM
Celen et al. 1996	42	60	160/95	106 (12–280)	NM	NM
Lo et al. 1996	44	77	160/95	51 (1–132)	1.5 (0.8–4.5)	13
Proye et al. 1998	100	56	160/95	69 (6–252)	NM	NM
Sirén et al. 1998	27	41	NM	76 (9–154)	1.5 (0.8–3.2)	0
Sapienza et al. 1999	18	46	NM	63 (8)	2.6 (0.8^#)	0
Shen et al. 1999	79	85	DBP<100	4–72	NM	5.0
Brunt et al. 2001	26	31	DBP<100	27.9 (2–72)	1.9 (1.2^#)	20.0
Sawka et al. 2001	93	33	140/90	29 (0.1–77.9)	NM	NM
Fukudome et al. 2002	46	72	140/90	292.8	1.47 (0.8*)	NM
Rossi et al. 2002	30	67	140/90	63 (26.1)	2.0 (1.12^#)	6.6
Harris et al. 2003	33	62	NM	5 (1–96)	NM	9.0
Meria et al. 2003	212	58	NM	44 (6–84)	1.76	10.0
Stowasser et al. 2003	14	50	140/90	10.5 (3–21)	NM	NM
Goh et al. 2004	42	50	NM	21 (1–60)	1.75 (0.6)	NM
Meyer et al. 2005	24	33	140/90	86 (48)	2.1 (0.9^#)	NM
Pang et al. 2007	62	34	140/90	59	1.7 (1.5–2.0)	8.0
Gockel et al. 2007	40	37	NM	45 (7–114)	1.8 (0.7–6.0)	2.5