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This Article Accepted manuscript (PDF) All Versions of this Article: ERC-08-0083v1 15/4/931    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Chargari, C. Articles by Magné, N. Search for Related Content PubMed PubMed Citation Articles by Chargari, C. Articles by Magné, N.

C Chargari, Paris, France
L Vedrine, Paris, France
O Bauduceau, Paris, France
S Le Moulec, Paris, France
B Ceccaldi, Paris, France
N Magné, Radiotherapy, institut Gustave-Roussy, Villejuif, 94805, France

Correspondence: Nicolas Magné, Email: nicolas.magne{at}igr.fr

Abstract

Recurrent meningiomas constitute an uncommon but significant problem after standard therapy failure. Speculation that meningiomas may be subject to endocrine influence was supported by both immunohistochemical analyses and epidemiological data. Therefore, alternative strategies such as endocrine therapy have been suggested. Although evidence of consistent findings for the role of specific hormonal exposures is mounting, there are numerous discrepancies about the mitogenic effect of hormonal manipulation on meningioma cells. A better understanding of the molecular mechanisms involved in meningioma pathogenesis may not only lead to the identification of novel diagnostic and prognostic markers but may also facilitate the development of new pathogenesis-based targeted strategies. This review of literature aims to summarize the present state-of-the-art of endocrine therapy in management of meningiomas, in order to establish whether hormonotherapy could be included in the therapeutic strategy for unresectable and/or progressive tumours in previously irradiated meningioma patients.